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GCOE Program Seminar

Date and Time: July 12 &s_comma; 2011 16:00 - 17:30
Venue : First building&s_comma; Auditorium&s_comma; Institute of Medical Science&s_comma; University of Tokyo
(Shirokane-dai station&s_comma; Nanboku/Mita line)
Speaker:Dr. Inder M. Verma&s_comma; Professor
Affiliation:The Salk Institute USA
Seminar Title:Glioblastomas: A Tale of Reprogramming&s_comma; Stem Cells and Transdifferentiation
Summary:We have generated mouse models of human glioblastoma multiforme (GBM) using lentiviral vectors&s_comma; which faithfully recapitulate the human disease. Our results show: 1. GBMs can originate in a variety of CNS cells transduced with appropriate oncogenes or loss of suppressor genes. 2. The transduced cells dedifferentiate to become neuro-progenitors&s_comma; capable of self-renewal and differentiation into most CNS lineages. 3. The tumor cells in the deep part of the tumor can transdifferentiate to become endothelial cells&s_comma; through which blood can flow. 4. Clinical samples from patients also show transdifferentiation. 5. We have started using small molecules capable of inhibiting the formation of transdifferentiated endothelial cells&s_comma; along with nano-medicine technologies to combat this deadly disease.