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第221回 Bone Biology Seminar



演題 “TEXTURE ANALYSIS IN QUANTITATIVE OSTEOPOROSIS ASSESSMENT:
SEGMENTATION AND CHARACTERIZING MICROARCHITECTURE”

演者 Alexander Valentinitsch

     Computational Image Analysis and Radiology Lab

Department of Radiology Medical University of Vienna

Austria

抄録   Currently&s_comma; the assessment of osteoporosis is mainly based on bone
mineral density (BMD) measurement as assessed by dual-energy x-ray
absorptiometry (DEXA). DEXA measurements cannot distinguish between the
separate contributions of cortical and trabecular bone&s_comma; or assess
3-dimensional geometry and microarchitecture.The microarchitecture of the
trabecular bone is an highly informative feature for osteoporosis
assessment. High resolution peripheral quantitative computed tomography
(HR-pQCT) permits its in-vivo observation at a resolution of 82 μm. We
propose an approach that assesses bone microarchitecture based on texture
features extracted from the trabecular bone. The method is based on
three-dimensional texture features as local descriptors of the structure in
the trabecular bone. A clustering in the feature space indicates
characteristic classes of microarchitecture that are repeatedly detected
across subjects. The distribution of those classes allows for a
differentiation between osteoporotic and healthy subjects. We report initial
results for the repeatability of the method and its performance for the
differentiation of healthy and osteoporotic subjects. Experiments also show
that the we can achieve a threshold-independent segmentation of cortical and
trabecular compartment by using texture analysis approach. It outperforms
the state of the art methods in terms of bias and accuracy. This results in
reliable thickness measurements&s_comma; and provides an accurate basis for the
study of the transitionary zone between cortical and cancellous bone.2010年12月2
日(木) 16:00~18:00

東京医科歯科大学

M&Dタワー24階セミナー室



問い合わせ先: 難治疾患研究所分子薬理学 野田政樹

TEL 03-5803-4057




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