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日時 : 平成22年 12月 6日 (月曜日) 10:00 ~ 11:30

会場 : (財)東京都医学研究機構 東京都臨床医学総合研究所 2階講堂

演題 : DNA damage signaling and DNA repair


演者 : Junjie Chen教授

Department of Experimental Radiation Oncology&s_comma; The University of Texas M. D.
Anderson Cancer Center&s_comma; 1515 Holcombe Boulevard&s_comma; Houston&s_comma; Texas 77030&s_comma; USA

Junjie Chen教授は動物細胞DNA損傷チェックポイントの研究分野での世界的権威です。今回、BMB2010のシンポジウムに招聘されるこの機会に臨床研セミナーでご講演いただくことになりました。午前中の早い時間ですが皆様のご来場をお待ちしております。

The ability to sense DNA damage and activate responsive pathways that coordinate cell cycle progression and DNA repair is critically important for the maintenance of genomic stability and tumor suppression. Kinase cascades&s_comma; initiated by ATM and ATR&s_comma; play critical roles in DNA damage response&s_comma; since they phosphorylate many substrates and regulate multiple aspects in the DNA damage responsive pathways. A recent development in the field is the discovery of ubiquitination-dependent signaling transduction pathway&s_comma; which works hand in hand with damage-induced phosphorylation events and contributes to the accumulation of many DNA damage repair proteins near DNA damage sites. We are now studying how these ubiquitin chains are regulated at sites of DNA breaks. In addition&s_comma; we identified a nuclease FAN1 (Fanconi anemia Associated Nuclease 1) that specifically associates with mono-ubiquitinated FANCD2/FANCI and participates in the repair of interstrand crosslinks. Collectively&s_comma; these s!
tudies highlight the importance of posttranslational modifications in the regulation of DNA damage signaling and DNA repair.


Science&s_comma; 316(5828):1202-5. 2007.; Nat Struct Mol Biol. 14(8):710-5&s_comma; 2007.; Cell&s_comma;
131(5):901-14&s_comma; 2007.; Nature&s_comma; 451(7178):583-6&s_comma; 2008.; J Cell Biol. 181(5):727-35&s_comma;
2008.; Proc. Natl. Acad. Sci. U.S.A.&s_comma; 105(32):11200-5&s_comma; 2008.; Nature Cell Biol.&s_comma;
10(9):1076-82&s_comma; 2008.; Nature Cell Biol.&s_comma; 11(2):204-10&s_comma; 2009.; Nature Cell Biol.&s_comma;
11(4):409-19&s_comma; 2009.; Nature Cell Biol.&s_comma; 11(5):592-603&s_comma; 2009.; Genes Dev. 23(6):719-28&s_comma;
2009.; Proc Natl Acad Sci U S A.&s_comma; 106(17):7155-60&s_comma; 2009.; Mol Cell 35(3):384-93&s_comma;
2009.; J Clin Invest 119(9):2714-24&s_comma; 2009.; Genes Dev. 23(20):2394-9&s_comma; 2009.; Mol Cell
37(3):438-46&s_comma; 2010.; Mol Cell 37(6):854-64&s_comma; 2010.; Science 329(5992):693-6&s_comma; 2010.

〔世話人:ゲノム動態プロジェクト 正井 久雄〕

Hisao Masai
Genome Dynamics Project&s_comma;
Tokyo Metropolitan Institute of Medical Science&s_comma;
2-1-6 Kamikitazawa&s_comma; Setagaya-ku&s_comma; Tokyo 156-8506&s_comma; JAPAN
Tel: 81-3-5316-3231 Fax: 81-3-5316-3145; E-mail: masai-hs@igakuken.or.jp

正井 久雄
東京都臨床医学総合研究所 ゲノム動態プロジェクト
郵便番号 156-8506
所在地  東京都世田谷区上北沢二丁目1番6号
正井直通電話 03-5316-3231
研究室電話 03-5316-3117
研究室FAX 03-5316-3145
E-mail masai-hs@igakuken.or.jp