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Neurochemistry Seminar Announcement

Deconstructing presynaptic trafficking machinery and neurotransmission

Ege Kavalali&s_comma; Ph.D.
Associate Professor&s_comma; Department of Neuroscience&s_comma;
U.T. Southwestern Medical Center&s_comma; Dallas&s_comma; Texas&s_comma; USA

Time: May 17th 2010 (Mon) 12:00~13:00
Place: Seminar Room 5 (Room 1303)&s_comma; 13th floor&s_comma; New Medical Research Building
Host: Haruhiko Bito&s_comma; Department of Neurochemistry (tel: 03-5841-3560)

A Neuroscience Lecture Series Supported by the Comprehensive Center of Education
and Research for Chemical Biology of the Diseases&s_comma; a Global COE Program from
MEXT.

Abstract:
Synaptic terminals give rise to synchronous&s_comma; asynchronous and spontaneous
neurotransmitter release that are distinguished by their Ca2+-dependence and
time course. This presentation will focus on our recent work&s_comma; which addresses
whether all forms of neurotransmission originate from the same synaptic vesicle
pool&s_comma; require dynamin-dependent endocytosis for their maintenance and activate
the same population of postsynaptic receptors. Our findings suggest that evoked
synchronous and asynchronous release originate from a single vesicle pool that
recycles rapidly in a dynamin-dependent manner leading to the activation of the
same set of postsynaptic NMDA receptors. In contrast&s_comma; an alternate vesicle pool
sustains spontaneous release&s_comma; in a manner that does not rely on canonical
dynamin activation&s_comma; and targets a distinct population of NMDA receptors
triggering independent postsynaptic signaling. In addition&s_comma; our recent work
provided molecular insight into how distinct synaptic vesicle associated SNARE
proteins may sustain functionally diverse forms of neurotransmission. Our
findings indicate that VAMP-4 and synaptobrevin-2&s_comma; two synaptic vesicle SNAREs&s_comma;
functionally diverge&s_comma; traffic semi-independently and support distinct forms of
neurotransmission.

Ege Kavalali 博士は プレシナプス小胞輸送の新進気鋭の研究者です。この度、御来日の
折に、ご講演いただく機会を得ましたので、興味のある方はどうか奮ってご参加下さい。




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