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神経生化学セミナーのご案内
Neurochemistry Seminar Announcement

Imaging the spatial dynamics of synaptic proteins in neurons: mechanisms and
functions

Paul De Koninck&s_comma; Ph.D.
Professor&s_comma; Cellular Neurobiolgy Unit&s_comma; Université Laval Robert-Giffard&s_comma; Québec&s_comma;
Canada

Time: May 6th 2010 (Thu) 12:00~13:00
Place: Seminar Room 5 (Room 1303)&s_comma; 13th floor&s_comma; New Medical Research Building
Host: Haruhiko Bito&s_comma; Department of Neurochemistry (tel: 03-5841-3560)

A Neuroscience Lecture Series Supported by the Comprehensive Center of Education
and Research for Chemical Biology of the Diseases&s_comma; a Global COE Program from
MEXT.

Paul De Koninck 博士は CaMKII 研究の第一人者として名高い新進気鋭の神経科学者で
す。この度、御来日の折に、ご講演いただく機会を得ましたので、興味のある方はどうか
奮ってご参加下さい。

References:

De Koninck P&s_comma; Labrecque S&s_comma; Heyes CD&s_comma; Wiseman PW. Probing synaptic signaling with
quantum dots. HFSP J. (2007) 1(1): 5-10.
Bayer K.-U.&s_comma; LeBel E.&s_comma; McDonald G.L.&s_comma; O’Leary H.&s_comma; Schulman H.&s_comma; De Koninck
P.(2006). Transition from reversible to persistent binding of CaMKII to
postsynaptic sites and NR2B. J. Neurosci. 26(4): 1164-74
Hudmon&s_comma; A.&s_comma; LeBel&s_comma; E.&s_comma; Roy&s_comma; H.&s_comma; Schulman&s_comma; H.&s_comma; Waxham&s_comma; N. & De Koninck&s_comma; P.
(2005). A mechanism for CaMKII clustering at synaptic and non-synaptic sites
based on self-association. J. Neurosci. 25: 6971-83
Dupont&s_comma; G.&s_comma; Houart&s_comma; G. & De Koninck&s_comma; P. (2003) Sensitivity of CaM kinase II to
the frequency of Ca2+ oscillations: A simple model. Cell Calcium 34: 485-497.
Bayer&s_comma; K.-U.&s_comma; De Koninck&s_comma; P. & Schulman&s_comma; H. (2002). Alternative splicing
modulates the frequency-dependent response of CaMKII to Ca2+ oscillations. EMBO
J. 21: 3590-3597.
Bayer&s_comma; K.-U.&s_comma; De Koninck&s_comma; P.&s_comma; Leonard&s_comma; A.S.&s_comma; Hell&s_comma; J.W. and Schulman&s_comma; H. (2001).
Interaction with the NMDA Receptor locks CaMKII in an Active State. Nature 411:
801-805.
De Koninck&s_comma; P. & Schulman&s_comma; H. (1998). Sensitivity of Ca2+/calmodulin-dependent
protein kinase II to the frequency of Ca2+ oscillations. Science 279: 227-230.




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