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Neurochemistry Seminar Announcement

“A septin-dependent diffusion barrier at dendritic spine necks in neurons”
followed by
“A postdoc meets the Otsuka way”

Tomoko TADA&s_comma; Ph.D.
Former postdoc at the Sheng Lab&s_comma; The Picower Institute for Learning and
Memory&s_comma; MIT&s_comma; Cambridge&s_comma; MA; and currently&s_comma;
Investigator&s_comma; Qs’ Institute&s_comma; Otsuka Pharmaceutical Co.&s_comma; Ltd.&s_comma; Tokushima

Time: January 15&s_comma; 2010 (Fri) 12:00~13:00
Place: Seminar Room N212&s_comma; 2nd floor&s_comma; New Medical Research Building
Host: Haruhiko Bito&s_comma; Department of Neurochemistry (tel: 03-5841-3560)

A Neuroscience Lecture Series Supported by the Comprehensive Center of
Education and Research for Chemical Biology of the Diseases&s_comma; a Global COE
Program from MEXT.

Synaptic plasticity is a fundamental property of neurons. Morphologically
and functionally&s_comma; dendritic spines dramatically change during development
and in response to synaptic activity. These dendritic spines come in a
variety of shapes&s_comma; as well as in a range of sizes&s_comma; and the strength of the
synapse is strongly correlated with its volume. In 2007&s_comma; our group reported
new insights into the structural role of the molecular complex containing
the septin cytoskeleton that was localized at the spine neck and which was
involved in the control of spine morphogenesis. Further ongoing studies now
suggest that septin may function as a diffusion barrier in the spine neck&s_comma;
implying a potential role as a barrier or gatekeeper for memory.
Then&s_comma; I recently moved from an academic environment to the Otsuka
Pharmaceutical Co.&s_comma; Ltd. in 2008. I am now “thinking”... How can I
contribute to helping patients&s_comma; how can I further polish my science&s_comma; and
what kind of scientist am I? I will discuss the intricacy of the decision
making process during the transition period and will share the joy and
sorrow of my new life.

多田智子博士はMITのMorgan Sheng研究室にてシナプス細胞骨格に関する先端的研究

Tada T&s_comma; Simonetta A&s_comma; Batterton M&s_comma; Kinoshita M&s_comma; Edbauer D&s_comma; Sheng M. Role of
Septin cytoskeleton in spine morphogenesis and dendrite development in
neurons. Curr Biol. 2007 Oct 23;17(20):1752-8.
Iida K&s_comma; Teng J&s_comma; Tada T&s_comma; Saka A&s_comma; Tamai M&s_comma; Izumi-Nakaseko H&s_comma; Adachi-Akahane S&s_comma;
Iida H.Essential&s_comma; completely conserved glycine residue in the domain III
S2-S3 linker of voltage-gated calcium channel alpha1 subunits in yeast and
mammals.J Biol Chem. 2007 Aug 31;282(35):25659-67.
Tada T&s_comma; Sheng M. Molecular mechanisms of dendritic spine morphogenesis. Curr
Opin Neurobiol. 2006 Feb;16(1):95-101.
Iida K&s_comma; Tada T&s_comma; Iida H. Molecular cloning in yeast by in vivo homologous
recombination of the yeast putative alpha1 subunit of the voltage-gated
calcium channel. FEBS Lett. 2004 Oct 22;576(3):291-6.
Tada T&s_comma; Ohmori M&s_comma; Iida H. Phe356 in the yeast Ca2+ channel component Mid1 is
a key residue for viability after exposure to alpha-factor. Biochem Biophys
Res Commun. 2004 Jan 16;313(3):752-7.
Tada T&s_comma; Ohmori M&s_comma; Iida H.Molecular dissection of the hydrophobic segments H3
and H4 of the yeast Ca2+ channel component Mid1. J Biol Chem. 2003 Mar

脳神経医学専攻 神経生化学分野
〒113-0033 東京都文京区本郷7-3-1
e-mail: hbito@m.u-tokyo.ac.jp
Tel: 03-5841-3559 Fax: 03-3814-8154