***** seminarMLから情報転載 *****

William Schafer博士は線虫C.エレガンスで最初にin vivoカルシウムイメージン
グによる神経活動の可視化を行ったことで著名です。この技術をベースに行動と
神経回路の関係を明らかにする先導的な研究を続けられています。来日の機会に
セミナーをお願いしましたのでどうぞお誘い合わせの上ご来聴ください。

-----------------------------------------------------------------------------------------
グローバルCOE特別セミナー
生物化学専攻セミナー

日時:平成21年12月7日(月)13:30~
場所:理学部3号館3階327号室
講師:William R. Schafer
MRC Laboratory of Molecular Biology(Cambridge &s_comma; England )

演題:Neuroimaging studies of C. elegans pain circuits

要旨:Elucidating the mechanisms by which nervous systems process
information and generate behaviour is among the fundamental problems of
biology. Ultimately&s_comma; it is desirable to understand these processes at
the most basic level&s_comma;that of molecules and cells. We are investigating
these questions using the nematode Caenorhabditis elegans&s_comma; which has an
anatomically simple and well-defined nervous system and is tractable to
molecular and classical genetic analysis. Using recently developed
methods for in vivo optical neuroimaging&s_comma; we are investigating how the
activities of individual neurons correlate with behaviour&s_comma; and how genes
with interesting behavioural phenotypes affect the activities of
individual neurons in defined neural circuits.
We are particularly interested in sensory circuits that mediate
responses to noxious stimuli. C.elegans contain polymodal neurons that&s_comma;
like mammalian pain-sensing nociceptors&s_comma; respond to aversive mechanical&s_comma;
chemical&s_comma; and thermal stimuli. The responses of these neurons are
modulated by monoamines as well as opioid signaling. We used these
neurons to investigate molecular mechanisms involved in the sensation of
harsh touch and extreme cold.
In addition&s_comma;we have identified interneurons that integrate convergent
sensory information and allow nocicetive and mechanosensory neurons to
modify each other’s response properties. We anticipate that these
studies will reveal basic conserved principles of sensory transduction
and neural circuit function.

最近の主な論文

Walker DS&s_comma; Vázquez-Manrique RP&s_comma; Gower NJD&s_comma; Gregory E&s_comma; Schafer WR&s_comma; Baylis
HA (2009) “Inositol 1&s_comma;4&s_comma;5-trisphosphate signalling regulates the
avoidance response to nose touch in Caenorhabditis elegans” Plos
Genetics 5: e1000636

Suzuki H&s_comma; Thiele T&s_comma; Faumont S&s_comma; Ezcurra M&s_comma; Lockery S&s_comma; Schafer WR. (2008)
"Functional asymmetry in C. elegans salt taste neurons and its
computational role in chemotaxis behaviour" Nature 454: 114-117.

Kindt KS&s_comma; Quast KB&s_comma; Giles AG&s_comma; De S&s_comma; Hendrey D&s_comma; Nicastro I&s_comma; Rankin CH&s_comma;
Schafer WR (2007) "Dopamine mediates context-dependent modulation of
sensory plasticity in C. elegans" Neuron 55: 662-676.

Kindt KS&s_comma; Viswanath V&s_comma; Macpherson L&s_comma; Quast K&s_comma; Hu H&s_comma; Patapoutian A&s_comma;
Schafer WR (2007) "Caenorhabditis elegans TRPA-1 functions in
mechanosensation." Nature Neurosci 10: 568-577.


世話人:理学系研究科生物化学専攻 飯野 雄一 (内線:28293)
------------------------------------------------------------------------------------------

-------------------------------------------
〒113-0033 東京都文京区本郷 7-3-1
東京大学大学院理学系研究科生物化学専攻教授
飯野 雄一

宅配便送付先
〒113-0032 東京都文京区弥生 2-11-16
理学部3号館2階224号室

Tel&s_comma; Fax: 03-5841-8293 (学内内線28293)
e-mail: iino@biochem.s.u-tokyo.ac.jp
URL: http://molecular-ethology.biochem.s.u-tokyo.ac.jp/IINO_lab_J.html
-------------------------------------------




seminarMLに関する情報は「バイオ関係者、皆のホームページ」特選MailingList_Forum欄でアクセスできる。