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演者:Professor Ivan Rodriguez (Dpt. of Zoology and Animal
Biology&s_comma; University of Geneva)
タイトル:Mammalian vomeronasal chemoreceptors: from genes to
抄録:Mammals heavily rely on olfaction to adequately interact
with each other and with their environment. They make use of seven
transmembrane G-coupled receptors to identify odorants and
pheromones. These receptors are present on dendrites of olfactory
sensory neurons located in the main olfactory or vomeronasal sensory
epithelia&s_comma; and pertain to the odorant&s_comma; TAAR&s_comma; and vomeronasal type 1
or 2 receptor superfamilies. We found that a fifth class of GPCR-
encoding genes&s_comma; the formyl peptide receptor-related genes&s_comma; are
expressed by mouse vomeronasal sensory neurons. Similar to the four
known olfactory receptor gene classes&s_comma; formyl receptors-like genes
encode seven transmembrane proteins&s_comma; and are characterized by
monogenic transcription and a punctate expression pattern in the
sensory neuroepithelium. In vitro expression of mouse formyl receptor-
like 1&s_comma; 3&s_comma; 4&s_comma; 6 and 7 provides sensitivity to disease/inflammation-
related ligands. Using an in situ approach combining whole mount
vomeronasal preparations with dendritic calcium imaging in the intact
neuroepithelium&s_comma; we observed neuronal responses to the same
molecules&s_comma; which therefore represent a new class of vomeronasal
agonists. Finally&s_comma; some of these agonists trigger by themselves
behavioral avoidance in mice. Taken together&s_comma; these results suggest
that formyl receptor-like proteins play an olfactory function
associated with the identification of pathogens&s_comma; or of pathogenic

演者:Professor Jing Wang (Division of Biological Sciences&s_comma;
University of California&s_comma; San Diego)
タイトル:The rules of innate odor preference in Drosophila
抄録:Information about the external world arrives at our brain
via sensory system. Sensory stimuli interact with receptor neurons in
the periphery to generate sensation. Interpretation of the peripheral
neural activity by the central circuitry leads to perception of the
external world. What features of an animal’s sensory world are
relevant to behavior? How are the important sensory cues processed in
the central brain to generate appropriate behavioral output? I am
going to present our recent research in the fly olfactory system. We
have found that innately attractive and aversive odorants are encoded
by separate labeled-line circuits. Experience-dependent plasticity
and physiologic modulation of olfactory sensitivity in these labeled-
line circuits have profound impact on olfactory behaviors.

東原 和成 (とうはら かずしげ)
東京大学 大学院 新領域創成科学研究科
先端生命科学専攻 分子認識化学分野
〒277-8562 柏市柏の葉5-1-5 東京大学 新領
域 生命棟 201
(tel)0471-36-3624 (Fax) 0471-36-3626