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グローバルCOEセミナー・神経機能セミナー

タイトル:The roles of non-cholinergic basal forebrain neurons in top-down attention

演者:Dr. Shih-Chieh Lin
National Institute on Aging / Duke University &s_comma; USA

日時: 平成21年7月31日(金) 午後0時~1時
場所: 東大医学系研究科教育研究棟13階1305号室(第8セミナー室)
http://www.u-tokyo.ac.jp/campusmap/cam01_02_09_j.html

問合せ:医学系研究科 神経機能解明ユニット 
河崎洋志 03-5841-3616&s_comma; kawasaki@m.u-tokyo.ac.jp
http://square.umin.ac.jp/top/

Abstract
Top-down attention is an essential cognitive function&s_comma; allowing for selective processing of sensory stimuli based on their motivational salience. Impairment in properly allocating top-down attention represents a key feature of many neuropsychiatric disorders&s_comma; such as schizophrenia&s_comma; Alzheimer’s disease and attention deficit disorder (ADD). A key neural system required for proper execution of top-down attention is the mammalian basal forebrain (BF). Whereas the BF literature has traditionally focused on the cholinergic neurons&s_comma; anatomical studies have in fact shown that non-cholinergic neurons constitute the majority of BF corticopetal projections but their functions are poorly understood. My recent work provides the first evidence that non-cholinergic BF neurons play an important role in top-down attention. I found that the motivational salience of attended stimuli is encoded by ensemble bursting of non-cholinergic BF neurons&s_comma; which in turn may enhance behavioral performance by affecting the activity of widespread cortical circuits. These results suggest that non-cholinergic BF neurons represent a novel candidate mechanism for top-down attention and may gate attention-related cortical responses.



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河崎 洋志 (Hiroshi Kawasaki)

東京大学大学院医学系研究科
神経機能解明ユニット

〒113-0033 東京都文京区本郷7-3-1
東京大学医学部2号館N103号室
tel 03-5841-3616
fax 03-3813-2739
e-mail; kawasaki@m.u-tokyo.ac.jp
web site; http://square.umin.ac.jp/top/



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