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IMSUT & RCAST
GCOE Program Seminar
< Global Education Seminar >

Date and Time: JULY 8&s_comma; 2009 17:00 - 18:00
Venue : 2nd building 2F large lecture room
Institute of Medical Science&s_comma; University of Tokyo
(Nanboku/Mita line&s_comma; Shirokane-dai station)
Speaker: Dr. Josef Penninger
Position : Scientific Director&s_comma; Professor
Affiliation:Institute of Molecular Biotechnology of the
Austrian Academy of Science (IMBA)&s_comma; Vienna&s_comma; and University of
Toronto&s_comma; Canada
(Country: Austria)
Seminar Title:Systemic modeling of human disease in flies
(Language: English)
Summary:
Dr. Penninger first generated RANKL deficient mice and showed that
RANKL-RANK pathway is important not only for osteoclastogenesis but
also for early differentiation of T and B cells&s_comma; lymph node
organogenesis&s_comma; and mammary gland development (Nature&s_comma; 1999; Cell&s_comma;
2000). He also showed that activated T cells are directly involved
in the bone loss and joint destruction by expressing RANKL on the
surface (Nature&s_comma; 1999). These findings have opened a novel research
field so called osteoimmunology. Furthermore&s_comma; he has identified roles
of various genes such as Cbl-b (Nature&s_comma; 2000)&s_comma; DREAM (Cell&s_comma; 2002)&s_comma;
AIF (Nature&s_comma; 2001; Cell&s_comma; 2007)&s_comma; PTEN (Cell&s_comma; 2002; Nature&s_comma; 2006)&s_comma; and
Collectrin (Nature&s_comma; 2006)&s_comma; in our body using gene disruption
techniques. Because of these outstanding achievement&s_comma; he became the
director of IMBA&s_comma; Austria&s_comma; at the age of 38. This time&s_comma; he will
introduce a new approach to identify disease related genes using
flies; a part of this work was published in recent Science (2009).

Host:Yoichiro Iwakura (Laboratory of Cell Biology)&s_comma;
Jun-ichiro Inoue (Division of Cellular and Molecular
Biology)]
****
Sumiko Watanabe
Inst.Med.Sci.&s_comma; Univ.Tokyo



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