***** seminarMLから情報転載 *****

IMSUT & RCAST GCOE Program Seminar
< Global Education Seminar >

Date and Time:June 29&s_comma; 2009 (Monday) 17:00 - 18:00
Venue : 1st building 2F conference room&s_comma; Institute of Medical
Science&s_comma; University of Tokyo
(subway Nanboku/Mita line&s_comma; Shirokane-dai station)
Speaker:Thomas J. McHugh&s_comma; Ph.D.
Position : Head
Affiliation:Laboratory for Circuit and Behavioral Physiology&s_comma; RIKEN
Brain Science Institute
Seminar Title:The Role of CA3 Transmission in the Acquisition and
Consolidation of Spatial Memory

The hippocampus is an area of the brain that plays a central role in
both the acquisition and long-term storage of memory of events&s_comma;
places and contexts. It contains multiple excitatory circuits that
converge on the CA1 region; the trisynaptic pathway (which carries
information from the entorhinal cortex à dentate gyrus à CA3 à CA1
à entorhinal cortex) and the monosynaptic pathway (which connects
entorhinal cortex à CA1 à entorhinal cortex). Using a transgenic
mouse that permits inducible and reversible inhibition of synaptic
transmission specifically in CA3 pyramidal cells&s_comma; we have addressed
the contribution of trisynaptic pathway to hippocampal memory
formation and consolidation. We have behavior and the in vivo
physiology data that suggest synaptic output from CA3 in the
trisynaptic pathway is dispensable for incremental spatial learning&s_comma;
but required for rapid&s_comma; one-trial contextual learning. Further&s_comma; in
examining the consolidation of hippocampal memory&s_comma; we have identified
behavioral and physiological deficits resulting from a post-training
blockade of the CA3 to CA1 circuit. Our results suggest that the post-
training integrity of the trisynaptic pathway and the ripple-
associated sleep reactivation of the hippocampal memory engram are
crucial for memory consolidation.

Host:Toshiya Manabe (Division of Neuronal Network)&s_comma;
Sumiko Watanabe (Division of Molecular and Developmental Biology)

Sumiko Watanabe
Inst. Med.Sci.&s_comma; Univ. Tokyo