***** seminarMLから情報転載 *****


演者:Dr. John Ngai
Coates Family Professor of Neuroscience Department of Molecular and Cell
Biology & Helen Wills Neuroscience Institute&s_comma; The University of
California at Berkeley&s_comma; USA

演題:Computational Approaches to the Elucidation of Olfactory
Receptor Structure and the Discovery of Novel Chemosensory Ligands

日時: 2008 年12 月18 日 (木) 16:00~17:00
場所: 東京大学医学部教育研究棟13階 第6セミナー室

Vertebrates recognize and discriminate thousands of odorants of diverse
molecular structure. How
is this process of molecular recognition accomplished? The identification
of an odorant
’s chemical
structure is thought to occur through the combinatorial integration from
multiple odorant receptors&s_comma;
each tuned to recognize different molecular features. Thus&s_comma; by elucidating
the molecular
specificities of the odorant receptors we will gain a better understanding
how information is
processed in the olfactory system. In addition&s_comma; knowledge of the molecular
principles underlying
odorant recognition will illuminate how these receptors are tuned to bind
and discriminate odorous
ligands. As an approach to addressing these issues&s_comma; we have focused on the
properties of the
family” G protein-coupled receptors expressed in the vertebrate olfactory
system. This receptor
family includes the putative pheromone-sensing receptors of the mammalian
vomeronasal system
and the amino acid sensing receptors of the fish olfactory system. Our
studies utilize computational
modeling approaches to reveal the ligand-receptor interactions in amino
acid receptors expressed in
the fish olfactory system. In addition&s_comma; we have developed and implemented a
computational screening strategy to identify novel high affinity receptor
agonists. Such ligands
provide useful tools for probing the molecular architecture of the receptor
ligand binding pocket.
Significantly&s_comma; the top compounds identified in this computational screen
also display robust
activities as odorants in vivo. Our virtual screening approach should be
applicable to the
identification of new bioactive molecules for probing the structure of
chemosensory receptors and
the function of chemosensory systems in vivo.

連絡先:坂野 仁(内線24396)&s_comma; 森 憲作(内線23467)

東京大学大学院 医学系研究科
機能生物学専攻 細胞分子生理学教室
津野 祐輔
TEL:03-5841-3473(内23473)&s_comma; FAX:03-5800-6845