京都薬科大学 国際シンポジウムが下記の要領で開催される。最新情報は「バイオ関係者、皆のホームページ」学会・補助金欄、もしくはHot Newsの上フレームにある分野別Hot Newsセミナー学会を選択してアクセスできる。
  バイオ関係の学会・セミナー情報は、毎日、午前・午後更新。どうぞ毎日2回以上ご確認ください。


●公的な学会、研究会の告知募集は無料掲載、企業が開催するセミナー告知は有料です。詳細はmiyata@nikkeibp.co.jpまでメールください。


国際シンポジウム:International Symposium on Integrated Medicinal Science - On the basis of traditional medicine to biomolecular system -

日時 2008年12月13日(土)10:00~18:25
会場 京都薬科大学 愛学館
主催 京都薬科大学21世紀COEプログラム「伝承からプロテオームまでの統合創薬の開拓」、京都薬科大学創薬科学フロンティア研究センター、京都薬科大学オープン・リサーチ・センター
協賛 日本薬学会、日本化学会

○プログラム

9:55 - 10:00
Welcome & Introductory Remarks Aigaku Hall (3rd Floor)
Yoshiaki kiso

=================================================
Young Investigatorsf Mini Symposium
=================================================

10:00 - 10:06
Y - 1
New Bioactive Saponin Constituents from Flower Buds of Camellia sinensis in China (Fujian Province)
Seikou Nakamura Sachiko Sugimoto Chihiro Yamashita Hisashi
Matsuda Masayuki Yoshikawa
Department of Pharmacognosy Center for Frontier Research in Medicinal Science Kyoto Pharmaceutical University Japan

10:06 - 10:12
Y - 2
Bioactivities and Chemical Structures of New Constituents from Rhodiola sachalinensis and R. crenulata
Xuezheng Li Seikou Nakamura Hisashi Matsuda Masayuki Yoshikawa Department of Pharmacognosy Center for Frontier Research in Medicinal Science Kyoto Pharmaceutical University Japan

10:12 - 10:18
Y - 3
Aquaporin-1 Is Involved in the Remodeling of Gastric Epithelium
Shusaku Hayashi Nobuaki Takahashi Aya Yamaguchi and Koji Takeuchi Department of Pharmacology and Experimental Therapeutics Kyoto Pharmaceutical University Japan

10:18 - 10:24
Y - 4
Involvement of Prostacyclin/IP Receptors in Decreased Acid Secretion of Damaged Stomach: Mediation by Somatostatin/SST2 Receptors
Hikaru Nishio Shun Terashima Michitaka Ogura Maya Honda and Koji Takeuchi Department of Pharmacology and Experimental Therapeutics Kyoto Pharmaceutical University Japan

10:24 - 10:30
Y - 5
Involvement of NADPH Oxidase on Ischemia/Reperfusion-Induced Mucosal Damage in Rat Stomachs
Akari Nakagiri1 2 Motonobu Murakami2 1 Department of
Pharmacology and Experimental Therapeutics Kyoto
Pharmaceutical University 2 Department of Pharmacotherapeutics Doshisha Womenfs College of Liberal Arts Japan

10:30 - 10:36
Y - 6
Familial Parkinsonfs Disease Related-Protein DJ-1 (PARK7) Has Neuroprotective Effect for Dopaminergic Neurons
Takashi Yanagida1 Kazuyuki Takata1 Yoshihisa Kitamura1 Takashi Taniguchi1 Hiroyoshi Ariga2 1 Department of Neurobiology and 21st Century COE Program Kyoto Pharmaceutical University 2 Department of Molecular Biology Graduate School of
Pharmaceutical Sciences Hokkaido University Japan

10:36 - 10:42
Y - 7
Effect of Polyamidoamine (PAMAM) Dendrimer on the Pulmonary Absorption of Poorly Absorbable Drugs
Dong Zhengqi Hidemasa Katsumi Toshiyasu Sakane Akira
Yamamoto Department of Biopharmaceutics Kyoto Parmaceutical University Japan

10:42 - 10:48
Y - 8
Total Synthesis of (-)-Zampanolide
Takuya Iwamoto Nobuyuki Kawai Junfichi Uenishi Department of Pharmaceutical Chemistry Kyoto Pharmaceutical University Japan

10:48 - 10:54
Y - 9
Total Synthesis of (-)-Aspergillide B
Sudhir M. Hande Junfichi Uenishi Department of Pharmaceutical Chemistry Kyoto Pharmaceutical University Japan

10:54 - 11:00
Y - 10
Synthesis of Biotin-Tagged Photoaffinity Probes for
Diketopiperazine-Based Anti-Microtubule Agents
Yuri Yamazaki1 Kyoko Kohno2 Hiroyuki Yasui2 Yoshiaki Kiso2
Miki Akamatsu3 Benjamin Nicholson4 Gordafaried
Deyanat-Yazdi4 Saskia Neuteboom4 Barbara Potts4 G. Kenneth
Lloyd4 and Yoshio Hayashi1 1School of Pharmacy Tokyo University of Pharmacy and Life Sciences Japan 2Kyoto Pharmaceutical University Japan 3Graduate School of Agriculture Kyoto University Japan 4Nereus Pharmaceuticals USA

11:00 - 11:06
Y - 11
Road to HTLV-I Protease Inhibition
Jeffrey-Tri Nguyen Meihui Zhang Ayako Itami Hikoichiro
Maegawa Keiji Nishiyama Tooru Kimura Yoshio Hayashi
Maosheng Cheng Yoshiaki Kiso Department of Medicinal
Chemistry Center for Frontier Research in Medicinal Science and 21st Century COE Program Kyoto Pharmaceutical University Japan


11:06 - 11:12
Y - 12
Multiple N-Methylation: A New Perspective in Peptide Chemistry
Jayanta Chatterjee12 and Horst Kessler2 1Department of Medicinal Chemistry Center for Frontier Research in Medicinal Science 21st Century COE Program Kyoto Pharmaceutical University Japan 2Center for Integrated Protein Science at the Department Chemie Technische Universit?t M?nchen Germany


11:22 - 11:28
Y - 13
Photo-Triggered Water-Soluble Paclitaxel Prodrug Using Novel Coumarin Type Protective Group
Mayo Noguchi1 Mariusz Skwarczynski1 Prakash Halan2 Shun
Hirota23 Tooru Kimura1 Yoshio Hayashi14 and Yoshiaki Kiso1
1Department of Medicinal Chemistry Center for Frontier Research in Medicinal Science and 21st Century COE Program Kyoto Pharmaceutical University 2Laboratory for Supramolecular Science Graduate School of Materials Science Nara Institute of Science and Technology 3PRESTO JST 4School of Pharmacy Tokyo University of Pharmacy and Life Sciences Japan

11:28 - 11:34
Y - 14
Enhanced Activity of Hydroxymethylcarbonyl-Containing
Inhibitors Targeting Malarial Plasmepsin
Koushi Hidaka1 Tooru Kimura1 Adam J. Ruben2 Tsuyoshi
Uemura1 Mami Kamiya1 Yoshio Hayashi13 Ernesto Freire2 and
Yoshiaki Kiso1 1Department of Medicinal Chemistry Center for Frontier Research in Medicinal Science 21st Century COE Program Kyoto Pharmaceutical University Japan 2Department of Biology and Johns Hopkins Malaria Research Institute Johns Hopkins University USA 3Department of Medicinal Chemistry Tokyo University of Pharmacy and Life Sciences Japan

11:34 - 11:40
Y - 15
O-Acyl Isopeptide Method: Toward Routine Preparation of
Difficult Peptides
Taku Yoshiya Atsuhiko Taniguchi Naoko Abe Nui Ito Youhei
Sohma Tooru Kimura Yoshiaki Kiso Department of Medicinal
Chemistry Center for Frontier Research in Medicinal Science 21st Century COE Program Kyoto Pharmaceutical University Japan


11:40 - 11:46
Y - 16
gClick Peptideh Using O-Acyl Isopeptide Method: Photo-Triggered Production of Alzheimerfs Disease-Related Amyloid ? Peptide from Water-Soluble Analogue
Atsuhiko Taniguchi1 Mariusz Skwarczynski12 Youhei Sohma13
Takuma Okada4 Keisuke Ikeda4 Halan Prakash5 Hidehito Mukai1 Tooru Kimura1 Yoshio Hayashi16 Shun Hirota5 Katsumi
Matsuzaki4 Yoshiaki Kiso1 1Department of Medicinal Chemistry Center for Frontier Research in Medicinal Science 21st Century COE Program Kyoto Pharmaceutical University Japan 2School of Molecular and Microbial Sciences University of Queensland Australia 3Department of Biochemistry and Molecular Biology The University of Chicago USA 4Graduate School of Pharmaceutical
Sciences Kyoto University Japan 5Graduate School of Materials Science Nara Institute of Science and Technology Japan 6Department of Medicinal Chemistry Tokyo University of Pharmacy and Life Sciences Japan


=================================================
Oral Presentations
=================================================

11:46 - 11:59
O - 1
Anti-Tumor Effect of Nanoparticles Containing Tocopheryl
Succinate
Susumu Hama Suguru Utsumi Kentaro KogureCDepartment of
Biophysical Chemistry Kyoto Pharmaceutical University Japan

11:59 - 12:12
O - 2
Amelioration of High-Fat Diet-Induced Adipose Accumulation and Fatty Liver in Group IVA Phospholipase A2-Knockout Mice
Satoshi Akiba Hiromi Ii Naoki Yokoyama Takashi Sato
Department of Pathological Biochemistry Kyoto Pharmaceutical University Japan

12:12 - 12:25
O - 3
Coiled-Coil Tag?Probe System for Quick Labeling of Membrane Receptors in Living Cells
Yoshiaki Yano Katsumi Matsuzaki Graduate School of
Pharmaceutical Sciences Kyoto University Japan

12:25 - 12:38
O - 4
Open the Way to Medicinal Processes by the Proteomic Sciences: How to Utilize the Protein Information for Drug Discovery
Kazuki Saito12 and Yoshiaki Kiso3 1Laboratory of Proteomic
Sciences 21st Century COE Program Kyoto Pharmaceutical
University 2RIKEN Systems and Structural Biology Center
3Department of Medicinal Chemistry Center for Frontier Research in Medicinal Science and 21st Century COE Program Kyoto Pharmaceutical University Japan


13:20 - 14:20 Poster Presentations in Room A33 ( 3rd Floor )

14:30 - 14:43
O - 5
Total Synthesis of Insulin Proteins by Use of Chemical Ligation
Youhei Sohma and Stephen B. H. Kent Department of Biochemistry and Molecular Biology Department of Chemistry Institute for Biophysical Dynamics The University of Chicago USA

14:43 - 14:56
O - 6
Synthesis of (+)-Negamycin as a Potential Drug Lead against Duchenne Muscular Dystrophy
Yoshio Hayashi12 Thomas Regnier2 Akihiro Taguchi1 Shigenobu Nishiguchi2 Masataka Shiozuka3 Ryoichi Matsuda3 Manabu Node4 and Yoshiaki Kiso2
1Department of Medicinal Chemistry Tokyo University of Pharmacy and Life Sciences 2Department of Medicinal
Chemistry and 4Department of Pharmaceutical Manufacturing
Chemistry Center for Frontier Research in Medicinal Science Kyoto Pharmaceutical University 3Department of Life Science University of Tokyo Japan

14:56 - 15:09
O - 7
Discovery of Cryptides Functional Cryptic Peptides Hidden in Protein Structures and Their Accumulative Signaling Mechanisms
Hidehito Mukai and Yoshiaki Kiso 21st Century COE Program
Kyoto Pharmaceutical University Japan

15:09 - 15:22
O - 8
Inhibitory Effects of Thunberginols from Sweet Hydrangea Leaf on Antigen-Induced Degranulation and Production of Cytokines in RBL-2H3 Cells
Hisashi Matsuda1 Qilong Wang1 Hiroki Hata1 Souichi Nakashima1 Yoshimi Oda1 Ai Kurume2 Hiromasa Uchimura3 Hidehito Mukai4 Kazuki Saito3 Masayuki Yamashita2 Yoshiaki Kiso4 and Masayuki Yoshikawa1 1Department of Pharmacognosy 21st Century COE Program Kyoto Pharmaceutical University 2Department of Functional Molecular Chemistry 21st Century COE Program Kyoto
Pharmaceutical University 3Laboratory of Proteomics Sciences 21st Century COE Program Kyoto Pharmaceutical University 4Department of Medicinal Chemistry 21st Century COE Program Kyoto Pharmaceutical University Japan

15:22 - 15:35
O - 9
Identification of a Triterpenoid Oleanolic Acid from Olea
europeaea Leaves as a Potent TGR5 Agonist
Hiroyuki Sato14 C?dric Genet2 Axelle Strehle12 Charles Thomas1 Mitsuhiro Watanabe15 Annelise Lobstein2 Alain Wagner2 Charles
Mioskowski2 Kristina Schoonjans16 R?gis Saladin3 Johan
Auwerx16 1Institut de G?n?tique et de Biologie Mol?culaire et Cellulaire (IGBMC) France 2Facult? de Pharmacie Universit? Louis Pasteur France 3PhyotoDia France 4Department of Epidemiology National Cardiovascular Center Research Institute Japan 5School of Medicine Keio University Japan 6Laboratory of Integrative and Systems Physiology Swiss Federal Institute of Technology Switzerland

15:35 - 15:48
O - 10
Synthesis of MCoTI-I a Circular Trypsin Inhibitor Isolated
from Momordica cochinchinensis
Dung Le Nguyen1 James P. Tam2 Annie Heitz3 Laurent Chiche3
Jean-Fran?ois Hernandez4 Tran-Chau Pham5 1SysDiag CNRS
FRE300 Montpellier France 2Vanderbilt University Nashville
USA 3CBS CNRS UMR5048 Montpellier France 4IBMM CNRS
UMR5247 Montpellier France; 5Center of Biotechnology National University of Hanoi Vietnam


=================================================
Invited Lectures
=================================================

16:05 - 16:35
L - 1
Regulation of Translation and mRNA Decay Mediated by Small
RNA in E. coli
Hiroji Aiba Division of Biological Science Graduate School of Science Nagoya University Japan

16:35 - 17:05
L - 2
Epigenetic Code by Arginine Methylation and Its Metabolic
Function
Akiyoshi Fukamizu Aspect of Functional Genomic Biology Center for Tsukuba Advanced Research Alliance (TARA) University of Tsukuba Japan


17:20 - 18:00
L - 3
Our Experience with the HIV-1 Protease is Teaching Us How to Deal with New Targets
Ernesto Freire The Johns Hopkins University USA

18:00 - 18:40
L - 4
Ghrelin Receptor Ligands : From Laboratory to Clinical Studies
J.A. Fehrentz1 L. Demange1 A. Moulin1 V. Guerlavais1 D.
Boeglin1 Delphine Mousseaux1 Joanne Ryan1 Didier Gagne1
Gilbert Berg?1 Jean Claude Galleyrand1 Daniel Perrissoud2 & Jean Martinez1 1Institut des Biomol?cules Max Mousseron UMR 5247 Universit?s Montpellier 1 et 2 CNRS Facult? de Pharmacie France 2Zentaris GmbH Frankfurt am Main Germany


18:40 - Mixer at Cafeteria ( 1st Floor )

=================================================
Poster Presentations
=================================================

P - 1
??Glucosidase Inhibitory Effect of Various Metal Ions and Their Complexes
Yutaka Yoshikawa1 Ryoko Hirata1 Hiromu Sakurai2 Hiroyuki Yasui1
1Department of Analytical and Bioinorganic Chemistry Kyoto Pharmaceutical
University 2Faculity of Pharmaceutical Sciences Suzuka University of Medical Science Japan

P - 2
Stability and Pharmacokinetic Features of the Collagen-Mimetic Polypeptides in
the Blood of Rats
Hiroyuki Yasui1 Hiroaki Matsumoto1 Mika Uehara1 Yutaka Yoshikawa1 and
Takaki Koide2 1Department of Analytical and Bioinorganic Chemistry Kyoto
Pharmaceutical University 2Department of Chemistry and Biochemistry Faculty
of Advanced Science and Engineering Waseda University Japan

P - 3
Aldosterone Nongenomically Enhances NADPH Oxidase- and
Mitochondria-Derived Reactive Oxygen Species Production in Myocytes
Kenta Tanaka Miyuki Kobara Masaki Abe Makoto Ohigashi Yugo Uchida
Shota Tsujimoto Hiroe Toba Tetsuo Nakata Department of Clinical
Pharmacology Kyoto Pharmaceutical University Japan

P - 4
The Influence of Uremic Serum and Uremic Toxins on Intestinal and Hepatic
Excretion of Pravastatin
Masayuki Tsujimoto1 Daisuke Hatozaki1 Hitoshi Yokota1 Daisuke Shima1 Taku Furukubo2 Satoshi Izumi2 Tomoyuki Yamakawa2 Masaki Otagiri3 Sumio
Hirata3 Kohji Takara1 Kohshi Nishiguchi1 1Department of Clinical Pharmacy
Kyoto Pharmaceutical University 2Shirasagi Hospital 3Graduate School of Pharmaceutical Sciences Kumamoto University Japan

P - 5
Nuclear Localization Mechanism of Hsp105?? and Its Possible Function in
Mammalian Cells
Youhei Saito Nobuyuki Yamagishi and Takumi Hatayama Department of
Biochemistry and Molecular Biology Kyoto Pharmaceutical University Japan

P - 6
Hsp105? Up-Regulates hsp70 Gene Expression through Signal Transducer and Activator of Transcription-3
Nobuyuki Yamagishi Youhei Saito and Takumi Hatayama Department of
Biochemistry & Molecular Biology Kyoto Pharmaceutical University Japan

P - 7
Inhibition of Group IV Phospholipase A2 Suppresses the Reesterification of Free Cholesterol but Not Formation of Foam Cells in Oxidized LDL-Stimulated Macrophages
Asuka Kuroda Hiromi Ii Satoshi Akiba Department of Pathological
Biochemistry Kyoto Pharmaceutical University Japan

P - 8
Inhibition of High-Fat Diet-Induced Fatty Streak Formation and Liver
Inflammation in Group IVA Phospholipase A2-Knockout Mice
Yuya Shigemura Hiromi Ii Satoshi Akiba Department of Pathological
Biochemistry Kyoto Pharmaceutical University Japan

P - 9
Suppression of High-Fat Diet-Induced Fat Deposition with Inflammation in the Liver in Group IVA Phospholipase A2-Knockout Mice
Naoki Yokoyama Hiromi Ii Satoshi Akiba Department of pathological
Biochemistry Kyoto Pharmaceutical University Japan

P - 10
Role of Cysteinyl Leukotrienes in the Development of Ischemia/Reperfusion-Induced Gastric Injury
Tohru Kotani Yoshino Komatsu Yuka Nakamori Kikuko Amagase Shinichi
Kato Koji Takeuchi Department of Pharmacology and Experimental
Therapeutics Kyoto Pharmaceutical University Japan

P - 11
Dual Role of Nitric Oxide in Gastric Hypersecretion in the Distended Stomach:Inhibition of Acid Secretion and Atimulation of Pepsin Secretion
Yasuyuki Ito1 Sayaka Okuda2 Fumikazu Ohkawa1 Shinichi Kato1
Shoji Mitsufuji2 Toshikazu Yoshikawa2 Koji Takeuchi1 Department of
Pharmacology and Experimental Therapeutics Kyoto Pharmaceutical
University 2Molecular Gastroenterology and Hepatology Kyoto Prefectural
University of Medicine Graduate School of Medical Science Japan

P - 12
Induction of Antral Ulcers by Alendronate a Nitrogen-Containing
Bisphosponate in Rat Stomachs
Yumi Ohashi Eitaro Aihara Kikuko Amagase Koji Takeuchi Department of Pharmacology and Experimental Therapeutics Kyoto Pharmaceutical
University Japan

P - 13
Aggravation by Clopidogrel an Antiplatelet Drug of Antral Lesions Induced by Indomethacin in Rats
Michitaka Ogura Hikaru Nishio Maya Honda Shinichi Kato Koji Takeuchi Department of Pharmacology and Experimental Therapeutics Kyoto
Pharmaceutical University Japan

P - 14
Roles of COX/PGS/EP4 Receptors in Healing of Indomethacin-Induced Small
Intestinal Lesions in Rats: Relation to VEGF Expression
Kohei Kamei Ryo Hatazawa Mayu Tanigami Kikuko Amagase Koji Takeuchi Department of Pharmacology and Experimental Therapeutics Kyoto
Pharmaceutical University Japan

P - 15
Pathogenic Roles of Enterobacteria and iNOS/NO in a Rat Model of Ischemic
Enteritis
Yoshino Komatsu Yuka Nakamori Tohru Kotani Shinichi Kato Koji Takeuchi
Department of Pharmacology and Experimental Therapeutics Kyoto
Pharmaceutical University Japan

P - 16
Importance of Muscarinic Acetylcholine Receptor Subtype 4 in
Carbachol-Induced Pepsinogen Secretion in Mice
Nobuaki Takahashi1 Takuya Endo1 Shusaku Hayashi1 Kikuko Amagase1
Minoru Matsui2 Susumu Okabe3 Koji Takeuchi1 1Department of
Pharmacology and Experimental Therapeutics Kyoto Pharmaceutical
University 2Faculty of Pharmacy Chiba Institute of Science 3Department of Pharmacology Faculty of Pharmaceutical Sciences Doshisha Women’s University Japan

P - 17
Evaluation of Blood Retention and Tissue Distribution of Lipid Nano Emulsion by 19F-NMR Spectroscopy Using Fluorine-19 Labeled ?-Tocopherol Derivative
Kei Asai1 Shigehiko Takegami1 Hidemasa Katsumi2 Ryouji Kawahara1 Akira Yamamoto2 Tatsuya Kitade1 1Department of Analyticalchemistry Kyoto
Pharmaceutical University 2Department of Biopharmaceutics Kyoto
Pharmaceutical University Japan

P - 18
19F-NMR Spectroscopic and Second-Derivative Spectrophotometric Study
on the Binding of Fluvastatin to Bovine Serum Albumin
Masanori Toyoda Shigehiko Takegami Hiromi Matsuo Tatsuya Kitade
Department of analytical chemistry Kyoto pharmaceutical university Japan

P - 19
Gene Responses of Pseudomonas aeruginosa Cells to Epithelial Cell Barriers
Naoki Hayashi1 Jun Okuda1 Taku Oshima2 Shu Minagawa1 Naotake
Ogasawara2 and Naomasa Gotoh1 1Department of Microbiology and Infection
Control Science Kyoto Pharmaceutical University 2Graduate School of
Information Science Nara Institute of Science and Technology Japan

P - 20
Phylogenic Analysis of Multidrug Resistant Pseudomonas aeruginosa (MDRP): Analysis of Resistance Mechanisms
Emi Kyutoku Kaoru Noguchi Kimiko Nakao Masatoshi Yoneda Chiharu
Murakami Toshihiro Terai Shu Minagawa and Naomasa Gotoh Department of Microbiology and Infection Control Science Kyoto Pharmaceutical University Japan

P - 21
Adaptation Mechanism of Serratia marcescens to Silkworm Environment
through the Two-Component Regulation System ArcA/B
Shinji Sawada1 Shu Minagawa1 Yui Imuta1 Kaneyoshi Yamamoto2 Akira
Ishihama2 Jun Okuda1 and Naomasa Gotoh1 1Department of Microbiology and Infection Control Science Kyoto Pharmaceutical University 2Department of
Frontier Bioscience Hosei University Japan

P - 22
The RND-Type Multidrug Efflux System MexAB-OprM of Pseudomonas
aeruginosa Selects Bacterial Languages 3-Oxo-Acyl-Homoserine Lactones for Cell to Cell Communication
Shu Minagawa Hiroyuki Inami Tomohisa Kato Shinji Sawada Jun Okuda
Naomasa Gotoh Department of Microbiology and Infection Control Science Kyoto Pharmaceutical University Japan

P - 23
Development of a Novel Transdermal Patch of Bisphosphonates for the
Treatment of Osteoporosis
Kosuke Kusamori1 Hidemasa Katsumi1 Asuka Ueda1 Mari Abe1 Ying-shu
Quan12 Fumio Kamiyama2 Toshiyasu Sakane1 Akira Yamamoto1 1Department of Biopharmaceutics Kyoto Pharmaceutical University 2CosMED Pharmaceutical Co. Ltd Japan

P - 24
Evaluation of Pulmonary Absorption and Safety of Alendronate
for the Treatment of Osteoporosis
Jun-ichi Sano1 Hidemasa Katsumi1 Maria Nakatani1 Mari Abe1 Kosuke
Kusamori1 Toshiyasu Sakane1 Toru Hibi2 Akira Yamamoto1 1Department of Biopharmaceutics Kyoto Pharmaceutical University Japan 2Teikoku Pharma USA Inc.
P - 25
Enhancing Effect of Polyamines on the Intestinal Absorption of Poorly
Absorbable Peptide and Protein Drugs and Relative Signal Transduction
Mechanism
Yang Gao Hidemasa Katsumi Toshiyasu Sakane Akira Yamamoto Department of Biopharmaceutics Kyoto Pharmaceutical University Japan

P - 26
Effect of Chitosan Nanoparticle on the Intestinal Absorption of Poorly
Absorbable Drugs
Chengyun Yan12 Hidemasa Katsumi1 Toshiyasu Sakane1 Akira Yamamoto1
1Department of Biopharmaceutics 21st Century COE Program Kyoto
Pharmaceutical University Japan 2 College of Chemistry & Pharmacy Jiamusi of University China

P - 27
Improvement of Intestinal Absorption of Poorly Absorbable Drugs by
Polyamidoamine (PAMAM) Dendrimers in the Rat Intestine
Yulian Lin Mariko Nishimi Maki Yamashita Hidemasa Katsumi Toshiyasu
Sakane Akira Yamamoto Department of Biopharmaceutics Kyoto
Pharmaceutical University Japan

P - 28
Involvement of Neutrophils in the Induction of Late Asthmatic Response
(LAR) in Mice
Takeshi Nabe Fusa Hosokawa Kouki Matsuya Masanori Fujii Shigekatsu
Kohno Department of Pharmacology Kyoto Pharmaceutical University Japan

P - 29
Neurodegeneration of Dopaminergic System Induced by Rotenone Is
Prevented by 4-PBA a Chemical Chaperone
Mari Abe Takashi Yanagida Yoshihisa Kitamura Kazuyuki Takata Takashi Taniguchi Department of Neurobiology and 21st Century COE Program Kyoto Pharmaceutical University Japan

P - 30
Noninvasive Analysis of Focal Ischemia in Rat Brains with MR Imaging
Kosuke Imaue Kazuyuki Takata Yoshihisa Kitamura Takashi Taniguchi
Department of Neurobiology 21st Century COE Program Kyoto
Pharmaceutical University Japan

P - 31
Stimulation of Nicotinic Acetylcholine Receptor Increases Microglial
Amyloid-?? Phagocytosis
Sachiko Kagitani Kazuyuki Takata Yoshihisa Kitamura Takashi Taniguchi
Department of Neurobiology 21st Century COE Program Kyoto
Pharmaceutical University Japan

P - 32

Neuroprotective Effects of Nicotine Against a 6-Hydroxydopamine-Induced Neurotoxity
Koji Kishimoto Takashi Yanagida Yoshihisa Kitamura Takashi Taniguchi Department of Neurology 21st Century COE Program Kyoto Pharmaceutical University Japan

P - 33
Accelerated Amyloid-? Clearance by Transplantation of Microglia
Hironori Tatsuda Kazuyuki Takata Yoshihisa Kitamura Takashi Taniguchi
Department of Neurobiology 21st Century COE Program Kyoto
Pharmaceutical University Japan

P - 34
Identification of Tyramine ?-Hydroxylase Gene and Distribution of
Octopaminergic Neurons in Planarian Dugesia japonica
Jun Tsushima1 Kaneyasu Nishimura2 Yoshihisa Kitamura1 Kanji Yoshimoto3
Takashi Taniguchi1 Kiyokazu Agata2 1Department of Neurobiology 21st
Century COE Program Kyoto Pharmaceutical University and 2Department of Biophysics Graduate School of Science Kyoto University 3Department of Legal Medicine Kyoto Prefectural University of Medicine Japan

P - 35
P2X7 Receptor Activation Is Involved in Microglial Neuroprotection against Focal Cerebral Ischemia in Rats
Koichiro Yamane Yoshihisa Kitamura Kazuyuki Takata Takashi Taniguchi
Department of Neurobiology 21st Century COE Program Kyoto
Pharmaceutical University Japan

P - 36
PARK7 Protects against Oxidative Stress-Induced Cell Death in Human
SH-SY5Y Cells
Atsuko Yamamoto Daijirou Yanagisawa Yoshihisa Kitamura Takashi
Taniguchi Department of Neurobiology and 21st Century COE Program Kyoto Pharmaceutical University Japan

P - 37
Microarray Analysis in the Dorsal Root Ganglion of Rats with
Paclitaxel-Induced Neuropathy
Kentaro Nishida12 Yasuo Takeda23 Kazuki Nagasawa1 Sadaki Fujimoto1 Katushi Yamada23 1Department of Environmental Biochemistry Kyoto
Pharmaceutical University 2Department of Clinical Pharmacy and
Pharmacology Graduate School of Medical and Dental Sciences Kagoshima
University 3Department of Clinical Pharmacy Kagoshima University Medical and Dental Hospital Japan

P - 38
Interaction of V3 Loop Fragments with Multivalent Anionic Porphyrins and Their Iron Complexes and Anti-HIV-1 Activities
Kenji Watanabe1 Shigeru Negi2 Eiichi Kodama3 Takeshi Naitoh3 Akiko
Kiriyama2 Yukio Sugiura2 Koji Kano1 1Department of Molecular Chemistry
and Biochemistry Doshisha University 2Department of Clinical Pharmacy Doshisha Woman’s University 3Institute for Virus Research Kyoto University
Japan

P - 39
Transfollicular Delivery of Liposomes Encapsulating Insulin via Iontophoresis for Diabetic Therapy
Kentaro Kogure1 Masahiko Yamamoto2 Misuzu Watanabe2 Akiyoshi Saito3 Kiyoshi Kanemura3 Hideyoshi Harashima2 Kazuaki Kajimoto2 1Department of Biophysical Chemistry Kyoto Pharmaceutical University 2Faculty of Pharmaceutical Sciences Hokkaido University 3TTI-ellebeau Inc. Japan

P - 40
Structures of Lanostane-Type Triterpenes and Constituents with
Anti-Invasion of HT1080 from Sclerotia of Inonotus obliquus
Masayuki Yoshikawa1 Junko Iwami1 Yasunobu Asao1 Xuezheng Li1 Souichi Nakashima1 Masaaki Aihara1 Seikou Nakamura1 Shuichi Mizuno2 Hisashi Matsuda1 1Department of Pharmacognosy 21st Century COE Program Kyoto Pharmaceutical University and 2Keitenkai Tohwa Hospital Japan

P - 41
Structures of New Flavonoids and Benzofunan Derivative as Well as Inhibitors of Degranulation in RBL-2H3 Cells from Brazilian Herbal Medicine Cissus sicyoides
Fengming Xu Seikou Nakamura Kaoru Sugawara Hisashi Matsuda Masayuki
Yoshikawa Department of Pharmacognosy 21st Century COE Program Kyoto
Pharmaceutical University Japan

P - 42
Hydrangeic Acid from the Processed Leaves of Hydrangea macrophylla var.
thunbergii as a New Type of Anti-Diabetic Compound
Hisashi Matsuda Chihiro Yamashita Hailong Zhang Seikou Nakamura and
Masayuki Yoshikawa Department of Pharmacognosy 21st Century COE
Program Kyoto Pharmaceutical University Japan

P - 43
Anti-Allergic and Anti-Inflammatory Constituents from Rhubarb
Hisashi Matsuda1 Hiroki Hata1 Kaoru Sugawara1 Supinya Tewtrakul1
Hiromasa Uchimura2 Hidehito Mukai3 Kazuki Saito2 Yoshiaki Kiso3 and Masayuki Yoshikawa1 1Department of Pharmacognosy 21st Century COE Program Kyoto Pharmaceutical University 2Laboratory of Proteomics Sciences 21st Century COE Program Kyoto Pharmaceutical University 3Department of Medicinal Chemistry 21st Century COE Program Kyoto Pharmaceutical University Japan

P - 44
New Synthetic Pathway for ?-Hexoulofuranosyl Saccharide
Atsushi Ueda and Junfichi Uenishi Department of Pharmaceutical Chemistry Kyoto Pharmaceutical University Japan

P - 45
Stereochemistry and Mechanistic Study of Intramolecular PdII-Catalyzed
Oxypalladation and 13-Chirality-Transfer Reaction
Yogesh Shankar Vikhe Nobuyuki Kawai and Junfichi Uenishi Department of Pharmaceutical Chemistry Kyoto Pharmaceutical University Japan

P - 46
Synthetic Studies Towards Apicularen A
Sanjay S. Palimkar Junfichi Uenishi Department of Pharmaceutical Chemistry Kyoto Pharmaceutical University Japan

P - 47
The Synthetic Study of a New Mutagenic Benzoazepinoquinolinone Derivative
Atsushi Muroyama1CMinoru Ozeki1CTetsuya Kajimoto1CTetsushi Watanabe2Manabu Node1 1Department of Pharmaceutical Technochemistry and 2Department of Public Health Kyoto Pharmaceutical University Japan

P - 48
Synthetic Study of Glycolipid Analogs Including Trisaccharide
Kenji Arimitsu 1 Hiroyuki Kimura 2 Tetsuya Kajimoto 13 Manabu Node 1
1Kyoto Pharmaceutical University 2Graduate School of Pharmaceutical
Sciences Kyoto University 3Suzuka University of Medical Science Japan

P - 49
Construction of Three Contiguous Stereogenic Centers via Asymmetric Michael Addition Using Recycle Type Chiral Amine
Shunsuke Ochi1 Minoru Ozeki1 Takahiro Katoh1 Tetsuya Kajimoto1 and
Manabu Node1 1Department of Pharmaceutical Manufacturing Chemistry 21st COE Kyoto Phamaceutical University Japan

P - 50
Verification Method for Disulfide Arrangement by In-Gel Protein Digestion
Hiromasa Uchimura1 Itsuki Yasuo2 Shizuyo Koide-Yoshida1 Takaaki
Mizuguchi2 Yoshiaki Kiso2 and Kazuki Saito13 1Laboratory of Proteomics Sciences 21st Century COE Program Kyoto Pharmaceutical University 2Department of Medicinal Chemistry Center for Frontier Research in Medicinal Science and 21st Century COE Program Kyoto Pharmaceutical University and 3RIKEN Systems and Structural Biology Center Japan

P - 51
A Large-Scale Preparation of Ectodomains of ErbB-4 a Carcinogenic
Membrane Protein in Cooperation with the EGF Receptor
Hiromasa Uchimura1 Shizuyo Koide-Yoshida1 Shinya Ogino2 Shigeyuki
Yokoyama34 Yoshiaki Kiso2 and Kazuki Saito13 1Laboratory of Proteomics Sciences 21st Century COE Program Kyoto Pharmaceutical University 2Department of Medicinal Chemistry Center for Frontier Research in Medicinal Science and 21st Century COE Program Kyoto Pharmaceutical University 3RIKEN Systems and Structural Biology Center and 4Department of Biophysics and Biochemistry Graduate School of Science University of Tokyo Japan

P - 52
Dimerization Arm-Mimetic Peptide: A Promising Medicinal Lead for a New
Type of Inhibitor against the EGF Receptor
Takaaki Mizuguchi1 Hiromasa Uchimura2 Taeko Kakizawa1 Tooru Kimura1 Shigeyuki Yokoyama34 Yoshiaki Kiso1 and Kazuki Saito23 1Department of Medicinal Chemistry Center for Frontier Research in Medicinal Science and 2Laboratory of Proteomic Sciences 21st Century COE Program Kyoto Pharmaceutical University 3RIKEN Systems and Structural Biology Center and 4Department of Biophysics and Biochemistry Graduate School of Science University of Tokyo Japan

P - 53
Plug-Plug Technique in Peptide Screening with Capillary Electrophoresis: A Versatile Approach to Discover Inhibitory Peptides against Medicinal Target Proteins
Kazuki Saito12 Mamiko Nakato3 Takaaki Mizuguchi3 Shinji Wada3 Hiromasa Uchimura1 Shigeyuki Yokoyama24 Hiroshi Hirota2 and Yoshiaki Kiso3 1Laboratory of Proteomic Sciences 21st Century COE Program Kyoto Pharmaceutical University 2Protein Research Group RIKEN Genomic Sciences Center 3Department of Medicinal Chemistry Center for Frontier Research in Medicinal Science and 21st Century COE Program Kyoto Pharmaceutical University 4Department of Biophysics and Biochemistry Graduate School of Science University of Tokyo Japan

P - 54
Synthesis and Physico-Chemical Characterisation of a Novel Library of
Glycopeptides and Glycolipids
Zyta Ziora12 Norbert Wimmer1 Istvan Toth12 1The University of Queensland School of Molecular and Microbial Sciences 2The University of Queensland Centre for Integrated Preclinical Drug Development
(CIPDD)-TetraQ-Pharmaceutics Australia

P - 55
Design Synthesis and Immunological Evaluation of Glycolipopeptides as Group A Streptococcal Vaccine Candidates
Mariusz Skwarczynski1 Yoshio Fujita1 Abu-Baker M. Abdel-Aal1 Norbert Wimmer1 Michael R. Batzloff2 Michael F. Good2 Istvan Toth1 1The University of Queensland School of Molecular and Microbial Sciences 2The Queensland Institute of Medical Research PO Royal Brisbane Hospital Australia

P - 56
Total Syntheses of (})-Hostmanin A and (})-Methyllinderatin
Junko Kitao Naoko Kitamura Ai Kurume Kazuya Tsunoda Masayuki YamashitaCDepartment of Functional Molecular Chemistry 21st Century COE Program Kyoto Pharmaceutical University Japan

P - 57
A Novel Skeleton Transformation of 2a-Substituted 2a8b-Dihydro-3H-benzo[b]cyclobuta[d]pyran-3-ones to 2-(2-Oxoethyl)-2H-1-benzopyrans Promoted by a Combination of ZnI2-Organic base-H2O
Kazuya Tsunoda 1 Navnath Dnyanoba Yadav 1 Masayuki Yamashita 1 Yumiko
Saya 1 Ai Kurume 1 Ikuo Kawasaki 12 Shunsaku Ohta1 1@Department of Functional Molecular Chemistry 21st COE Program Kyoto Pharmaceutical University 2School of Pharmaceutical Sciences Mukogawa Womenfs University Japan

P - 58
O-Acyl Isopeptide Method for Peptide Synthesis: Application of O-Acyl
Isodipeptide Unit to the Synthesis of A?1?42 Isopeptide
Naoko Abe Atsuhiko Taniguchi Taku Yoshiya Setsuko Nakamura Nui Ito
Fukue Fukao Youhei Sohma Mariusz Skwarczynski Tooru Kimura Yoshio
Hayashi and Yoshiaki Kiso Department of Medicinal Chemistry Center for Frontier Research in Medicinal Science 21st Century COE Program Kyoto Pharmaceutical University Japan

P - 59
The Development of a Novel S-Acyl Isopeptide Method for the Efficient
Synthesis of Difficult Sequence-Containing Peptide
Nui Ito Taku Yoshiya Tooru Kimura Yoshiaki Kiso Department of Medicinal Chemistry Center for Frontier Research in Medicinal Science 21st Century COE Program Kyoto Pharmaceutical University Japan

P - 60
Design of BACE1 Inhibitors Containing Pyridine Derivatives
Hiroko Ohta1 Yoshio Hamada1 Naoko Miyamoto1 Ryoji Yamaguchi1 Abdellah Yamani1 Koushi Hidaka1 Tooru Kimura1 Kazuki Saito1 Shoichi Ishiura2 and Yoshiaki Kiso1 1Department of Medicinal Chemistry Center for Frontier Research in Medicinal Science 21st Century COE Program Kyoto Pharmaceutical University and 2Department of Life Sciences Graduate School of Arts and Sciences University of Tokyo Japan

P - 61
Significance of Interaction of BACE1-Arg235 with BACE1 Inhibitors
Daisuke Hamada Yoshio Hamada Hiroko Ohta Naoko Miyamoto Takashi
Hamada Tomoya Nakanishi Moe Yamasaki Abdellah Yamani Kazuki Saito
and Yoshiaki Kiso Department of Medicinal Chemistry Center for Frontier Research in Medicinal Science and 21st Century COE Program Kyoto Pharmaceutical University Japan

P - 62
Synthesis of Imino-Digitoxose Derivative Using L-Threonine Aldolase
Toshihiro Nishiyama Tetsuya Kajimoto Manabu Node Department of
Pharmaceutical Manufacturing Chemistry Kyoto Pharmaceutical University Japan




参加費 無料

参加申込方法 
下記の申込先へEmailまたはFaxにてお申込みください。
申込方法、最新情報など詳しくはホームページ
http://www.kyoto-phu.ac.jp/coe/ims2008/
をご覧ください。


問合・申込先
〒607-8412 京都市山科区御陵四丁野町1 京都薬科大学創薬科学フロンティア研究センター 
21世紀COEプログラム拠点リーダー 木曽良明(担当:COE拠点室)
Tel 075-595-4636 Fax075-595-4787
Email:coe@mb.kyoto-phu.ac.jp



統合創薬科学フロンティアシンポジウム
~伝承薬から生物分子システムまでを基盤として~



日時 2008年12月14日(日)10:00 ~ 16:00
会場 京都薬科大学 愛学館
主催 京都薬科大学21世紀COEプログラム「伝承からプロテオームまでの統合創薬の開拓」、京都薬科大学創薬科学フロンティア研究センター、京都薬科大学オープン・リサーチ・センター
協賛 日本薬学会、日本化学会

○招待講演 10:00~16:00
薬食同源の視点からメタボリックシンドローム予防物質の探索
(京薬大)吉川雅之
海洋生物資源からの新しい医薬シーズの探索
(大阪大)小林資正
ドラマタイプ手法とマルチテンプレート手法による生物活性物質の創製
(東京大)橋本祐一
スーパー人工核酸BNA -- 開発と応用 –
(大阪大)今西武
アルギニンペプチドを用いた細胞内デリバリー
(京都大)二木史朗
新規生体内ペプチドの探索・発見から臨床応用へ
(国立循環器病センター)寒川賢治
生物分子システムを基盤とする創薬科学
(京薬大)木曽良明

参加費 無料 

参加申込方法 
下記の申込先へEmailまたはFaxにてお申込みください。
申込方法、最新情報など詳しくはホームページ
http://www.kyoto-phu.ac.jp/coe/souyaku2008/
をご覧ください。


問合・申込先 
〒607-8412 京都市山科区御陵四丁野町1 京都薬科大学創薬科学フロンティア研究センター
21世紀COEプログラム拠点リーダー 木曽良明(担当:COE拠点室)
Tel 075-595-4636 Fax075-595-4787
Email:coe@mb.kyoto-phu.ac.jp