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会場:東京大学 医学部教育研究棟13F 第8セミナー室

講師:Dr. Thomas N. Sato&s_comma; Ph.D.
Department of Cell and Developmental Biology
Weill Medical College of Cornell University

演題:Cardiovascular Development&s_comma; Function and Disease: Chemistry to

During the last century&s_comma; the life processes have been mainly viewed as a
“chemical machine”. This mainstream view has been represented by the huge
leap made by biochemistry&s_comma; molecular biology and genetics since the beginning of
20th century until now. However&s_comma; in the last 10 - 15 years&s_comma; another approach&s_comma;
that is mostly based on physical and mechanical principles&s_comma; to describe the
processes of life has emerged. This latter approach is&s_comma; at the moment&s_comma; mostly
reflected by system biology&s_comma; synthetic biology&s_comma; bioengineering and
nanobiotechnology. In the past&s_comma; my laboratory has revealed several molecular
(i.e. chemical) components that play important roles in the development&s_comma;
physiological function&s_comma; and diseases of the cardiovascular system. Most recently&s_comma;
we have also begun to understand developmental and functional processes of the
cardiovascular system based on the physical and mechanical principles. In my
talk&s_comma; I would like to discuss both chemical (i.e.&s_comma; biochemistry&s_comma; molecular biology&s_comma;
genetics) and physical/mechanical approaches that we are employing to
understand the dynamic nature of the life processes&s_comma; mostly using the
cardiovascular system as a model system.
The cardiovascular system is the first organ to develop during
embryogenesis. It is also one of the most vital organ in the body. In the past
fifteen years&s_comma; my laboratory has used extensive molecular&s_comma; genetic and cell
biological tools to reveal central molecular players for the development of the
vascular system. In the first part of my talk&s_comma; I will summarize such discoveries&s_comma;
in particular the roles of Tie receptors and angiopoietins in vascular development&s_comma;
and the roles of VEGF and angiopoietin signaling in the regulation of arterial
and venous differentiation. I will also discuss our most recent studies on the
mechanisms underlying the blood vessel formation using a various novel imaging
tools&s_comma; as well as by using the principles of mechanical physics and stochastic
fluctuation models. In the second part of my talk&s_comma; I will discuss our most recent
effort to establish the mechanical model for the physiological function of the
heart based on the principles of fluid-dynamics&s_comma; and also to identify molecules
that play essential roles in the pumping of the heart. The third part of my talk
will focus on our most recent discovery of a critical biochemical signaling
pathway in the ischemia induced myocardial infarction&s_comma; one of the most
prevalent and fatal diseases in human society. At the end of my talk&s_comma; I would
like to discuss how I envision our approaches based on both chemical and
physical principles may impact the future advancement of life science and

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 栗原 裕基
 分子細胞生物学専攻 代謝生理化学分野
 Tel. 03-5841-3496 Fax. 03-5684-4958