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演題:Boredom and excitement: Genetic analysis of neural circuit development
and function in zebrafish.
演者:John Y. Kuwada 博士
所属:Dept. of Molecular&s_comma; Cellular and Developmental Biology&s_comma;
University of Michigan&s_comma; USA
日時: 平成20年7月23日(水)16:00~17:00
場所: 東京大学(本郷キャンパス)理学部2号館2F 201号室。アクセスについてはこ
連絡先: 東大・新領域 能瀬聡直 (04-7136-3919/03-5841-8724)
     東大・理   武田洋幸(03-5841-4431) 

 Forward genetic analysis of behavior in zebrafish can be useful for
identification of genes important for neural circuit development and
function. Normally tactile stimulation induces vigorous escape swimming in
zebrafish embryos. In ennui mutants (boredom in French) touch initiates only
weak swimming due to aberrant localization of acetylcholine receptors on
skeletal muscles. This phenotype is caused by a mutation in a member of the
low-density lipoprotein receptor family. Another mutation is the touch
unresponsive touchdown mutation (the apex of excitement in American
football) that arises from mutations in the gene encoding for a member of
the Transient Receptor Potential family of membrane channels. touchdown
mutants fail to respond to light touch&s_comma; but respond to various forms of
noxious stimuli. Our analysis suggests that the touchdown gene is a
component of the physiological pathway responsible for transduction of
nonpainful&s_comma; tactile stimuli.