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臨床研セミナーのご案内

東京都臨床医学総合研究所において、下記セミナーを開催いたします。
事前連絡など不要ですので、皆様ふるってご参加ください。

日時: 平成19年12月17日(月曜日)10:30~12:00

会場: (財)東京都医学研究機構 東京都臨床医学総合研究所 2階 会議室
臨床研へは http://www.rinshoken.or.jp/intro/map.htm をご参考ください。

演題: Programming DNA replication origins on chromatin during cell
division and differentiation

演者: Marcel MECHALI博士&s_comma; Institute of Human Genetics&s_comma; CNRS&s_comma; 141
rue de la Cardonille&s_comma; 34396 Montpellier&s_comma; France.

MECHALI博士は、DNA複製の細胞周期および発生過程での制御機構の研究などで
著名です。今回BMB2007のシンポジウムに招聘されたこの機会に臨床研でセミ
ナーをしていただくことになりました。

《要旨》
In multicellular eukaryotes&s_comma; DNA replication origins are localized at
specific sites along the genome&s_comma; but they do not share a consensus
sequence. We suggested that a transition from strict
sequence-specific features to an epigenetic control linking DNA
replication origin selection with transcription contributes to
development. In a first part of this seminar&s_comma; I will report that DNA
replication origin selection is determined by the cell fate both in
Xenopus and in mouse. In Xenopus&s_comma; DNA replication origins are
developmentally regulated&s_comma; and correlate with the organization of
chromatin domains. Reprogramming of replicons and chromatin
organization also occurs during transfer of differentiated nuclei
into eggs. Mitosis is necessary for this reprogramming and involves a
topoisomeraseII-dependent process. We have also addressed the
regulation of DNA replication origins selection during neural
differentiation in the mouse HoxB domain&s_comma; a 120 Kbp cluster of nine
genes developmentally regulated. We observed a reorganization of the
HoxB domain for DNA replication when the HoxB domain is activated.
In a second part of this talk&s_comma; I will address how DNA
replication origins are assembled and controlled. The role of Cdt1&s_comma;
geminin&s_comma; and the recently discovered MCM9 protein will be particulary
presented.

Lutzmann et al&s_comma; (2006) EMBO J. 25&s_comma; 5764-5774.
Greoire&s_comma; et al&s_comma; (2006) EMBO Rep.&s_comma; 7&s_comma; 812-816.
Lemaitre&s_comma; et al&s_comma; (2005) Cell&s_comma; 123&s_comma; 787-801.
Maiorano et al (2005) Cell&s_comma; 120&s_comma; 315-28.
Danis et al&s_comma; (2004) Nature Cell Biol.&s_comma; 6&s_comma; 721-730.
Mehali&s_comma; M. (2001) Nat. Rev. Genetics&s_comma; 8&s_comma; 640-645.


<連絡先>
東京都臨床医学総合研究所
ゲノム動態プロジェクト
正井久雄
電話 03-5685-2264


--
Hisao Masai
Genome Dynamics Project&s_comma;
Tokyo Metropolitan Institute of Medical Science&s_comma;
3-18-22 Honkomagome&s_comma; Bunkyo-ku&s_comma; Tokyo 113-8613&s_comma; JAPAN
Tel: 81-3-5685-2264; Fax: 81-3-5685-2932; E-mail: hmasai@rinshoken.or.jp
http://www.rinshoken.or.jp/CB/index-jp.htm





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