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先端ライフワークショップ 幹細胞の制御と骨



東京医科歯科大学 難治疾患研究所



学術振興会 先端研究拠点事業  http://www.tmd.ac.jp/mri/abjs/

 

東京医科歯科大学1号館9階特別講堂 10月28日(日)

 東京医科歯科大学歯学部4階特別講堂 10月29-31日(月―水)



参加費: 無料




【申込先】 東京医科歯科大学 難治疾患研究所 分子薬理学 〒101-0062 東京都千代田区神田駿河台2-3-10 tel/fax 03-5280-8067

浦田圭乃 E-mail: turata.mph.mri.tmd.ac.jp (住所・氏名・所属をお知らせ下さい)




“Stem Cell Regulation and Bone “

―Symposium and Workshop―

Advanced Bone and Joint Science (ABJS)

International Collaboration Symposium between

Core to Core Program of Japanese Society for Promotion of Science (JSPS) 
and

Canadian Arthritis Network (CAN)&s_comma; Network of Centres of Excellence

Co-sponsored by;

21st Century Center of Excellence (COE) Program

“Molecular Destruction and Reconstruction of Tooth and Bone”



Venue: Tokyo Medical and Dental University

     October 28&s_comma; 2007 Auditorium&s_comma; Bldg 1 (9F )

October 29-31&s_comma; 2007 Auditorium&s_comma; Dental School (4F )



(Core to Core program&s_comma; Supported by Japanese Society for Promotion of
Science http://www.jsps.go.jp/j-bilat/core_to_core/index.html).









Sunday&s_comma; October 28&s_comma; 2007

ABJS Symposium in collaboration with Canadian Arthritis Network

Introduction

10:30 Masaki Noda&s_comma; Tokyo Medical and Dental University

Microenvironmental regulation of cells

Session S-1: Canadian and Japanese Arthritis Research

Moderators: Jane Aubin&s_comma; Masaki Noda

10:45 Johnathan M Riley&s_comma; Canadian Arthritis Network

CAN: a model for network research

11:10 Nobuyuki Miyasaka&s_comma; Tokyo Medical and Dental University

Treatment strategies of rheumatoid arthritis in Japan; Present and future

11:35 Jean Legare&s_comma; Consumer Advisory Council Emeritus Member

The Canadian Arthritis Network’s unique model of consumer involvement in
research

12:00-12:50 Break

Session S-2: Mesenchymal Cells and Organogenesis

Moderators: Bill Stanford&s_comma; Nobuyuki Miyasaka

12:50 Jane Aubin&s_comma; University of Toronto

Leukemia inhibitory factor effects on mesenchymal cell fate choice
and osteogenesis

13:50 Makoto Asashima&s_comma; University of Tokyo

In vitro organogenesis and transplantation in vertebrate development



Session S-3: Molecular Bases for Skeletogenesis and Stem Cell Niche

Moderators: Henry Kronenberg&s_comma; James R. Woodgett

14:50 Michael Underhill&s_comma; University of British Columbia

Delineating the molecular mechanisms underlying chondrogenesis

15:50 Toshio Suda&s_comma; Keio University

Quiescent hematopoietic stem cells in the endosteal niche

16:500-17:00 Break

Session S-4: Humoral and Cellular Control of Bone Metabolism

Moderators: Shigeaki Kato&s_comma; Levent Akyurek

17:00 Yoichi Nabeshima&s_comma; Kyoto University

Alpha-Klotho: a regulator that integrates calcium homeostasis





Bone Biology Lecture  Moderator: Masaki Noda

18:00 Henry Kronenberg&s_comma; Harvard University&s_comma;

Periosteal origin of the first osteoblasts in the primary spongiosa

19:05 Social Hour with Buffet (Medico、16F&s_comma; Bldg. B)



========================================================

ABJS Workshop in collaboration with Canadian Arthritis Network

Monday&s_comma; October 29&s_comma; 2007

Session M-1: Stem Cell Control and Skeletogenesis

Moderators: Michael Underhill&s_comma; Toshihisa Komori

9:00 Marius Wernig&s_comma; Whitehead Institute for Biomedical Research

Epigenetics of stem cell differentiation

10:00 Ung-il Chung &s_comma; Univ of Tokyo

Development of high-performance implant devices

11:00 Levent Akyurek&s_comma; Goteborg University

Filamin B deficiency in mice results in skeletal malformations and
impaired microvascular development

12:00-13:00 Break

Session M-2: Molecular Signaling in Cell Differentiation

Moderators: Anita Woods&s_comma; Keiji Moriyama

13:00 Hiroshi Takayanagi&s_comma; Tokyo Medical and Dental University

Molecular mechanism of osteoclast differentiation

14:00 James R. Woodgett&s_comma; Samuel Lunenfeld Research Institute

Genetic analysis of the roles of glycogen synthase kinase-3 in stem
cell fate determination and signaling

Official Address

15:00 President Address Akio Suzuki

Tokyo Medical and Dental University

     Ministry of Education&s_comma; Culture&s_comma; Sports&s_comma; Science and Technology

TBA

Director Address Hiromichi Matsuo

International Program Department
Japan Society for the Promotion of Science



Session M-3: Nuclear Events and Bone Regulation

Moderators: Marius Wernig&s_comma; Hiroshi Takayanagi

15:30 Shigeaki Kato&s_comma; University of Tokyo

Osteoprotective action of sex hormones mediates nuclear sex
hormone receptors in osteoclasts

16:30 Konrad Hochedlinger&s_comma; Center for Cancer Research&s_comma; Massachusetts General
Hospital&s_comma; Harvard University

Nuclear reprogramming and pluripotency

17:30 Hiroshi Kawaguchi&s_comma; University of Tokyo

Transcriptional regulation of cartilage degradation during
osteoarthritis





Tuesday October 30&s_comma; 2007

Session T-1: Regulatory Signaling in Bone Cells

Moderators: Bill Stanford&s_comma; Akira Yamaguchi

9:00 Henry Kronenberg&s_comma; Harvard University

PTH receptor signals that regulate development of osteoblasts

10:00 Toshihisa Komori&s_comma; Nagasaki University

Regulation of skeletal development and maintenance by Runx2

11:00 Jane Aubin&s_comma; University of Toronto

  Estrogen receptor-related receptors in skeletogenesis



12:00-13:00 Break

Session T-2: Mesenchymal Cell Differentiation and Signaling

Moderators: Jane Aubin&s_comma; Takeshi Muneta

13:00 Bill Stanford&s_comma; University of Toronto

Defining the Mesenchymal Stem Cell - clonality and function

14:00 Anita Woods&s_comma; University of Western Ontario

Rho signalling pathways in chondrocyte differentiation and function

15:00 Hiroshi Kawaguchi&s_comma; University of Tokyo

Bone regeneration by FGF signaling

16:00-16:10 Break



Session T-3: Central System and Skeletogenesis

Moderators: Michael Underhill&s_comma; Hiroshi Kawaguchi

16:10 Shu Takeda&s_comma; Tokyo Medical and Dental University

  A new aspect of central control of bone remodeling

17:10 Kenichi Shinomiya&s_comma; Tokyo Medical and Dental University

Fundamental and clinical study of magnetic field potentials of the
cervical spinal cord for evaluation of spinal cord function





Wednesday October 31&s_comma; 2007

Session W-1: Nuclear Control of Cell Fate

Moderators: Kazuhisa Nakashima&s_comma; Koichi Matsuo

9:00 James R. Woodgett&s_comma; Samuel Lunenfeld Research Institute

  Regulation of nuclear oncogene functions by phosphorylation

10:00 Shigeaki Kato&s_comma; University of Tokyo

A novel signaling pathway of fat-soluble ligands of transcriptional
factor-type receptors through target protein degradation

11:00 Konrad Hochedlinger&s_comma; Center for Cancer Research&s_comma; Massachusetts General
Hospital&s_comma; Harvard University

Epigenetic reprogramming of adult cells by defined transcription factors

12:00-13:00 Break

Session W-2: Molecular Bases of Cell Regulation

Moderators: Konrad Hochedlinger&s_comma; Ikuo Morita

13:00 Koichi Matsuo&s_comma; Keio University

Ephrin function in bone cell interaction

14:00 Levent Akyurek&s_comma; Goteborg University

Filamin A promotes VEGF-A activity through the HIF-1α-mediated hypoxic
response

15:00 Marius Wernig&s_comma; Whitehead Institute for Biomedical Research

Generation of pluripotent stem cells through direct reprogramming of
fibroblasts

16:00 Closing

Masaki Noda&s_comma; Tokyo Medical and Dental University





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