***** seminarMLから情報転載 *****

東京大学 グローバルCOE『統合生命学』特別セミナー

演者:Dr. Robert Lucas
University of Manchester&s_comma; UK

演題:The form and function of mammalian inner retinal photoreceptors

Among the most surprising recent discoveries in visual science has been that
rods and cones are not the only cells in the mammalian retina capable of
responding directly to light. Rather&s_comma; a small number of the cells whose
axons form the optic nerve (retinal ganglion cells) are intrinsically
photosensitive and are able to signal information regarding the overall
quantity of light in the environment (irradiance) to the brain. They attain
this remarkable ability through expression of an opsin based photopigment
called melanopsin. In this presentation I will review the discovery and
characterisation of these photoreceptors&s_comma; and continue to describe our
ongoing attempts using transgenic mice and cell culture methods to
investigate how they work&s_comma; and the contribution that they make to mammalian

Bellingham J&s_comma; Chaurasia SS&s_comma; Melyan Z&s_comma; Liu C&s_comma; Cameron MA&s_comma; Tarttelin EE&s_comma;
Iuvone PM&s_comma; Hankins MW&s_comma; Tossini G&s_comma; Lucas RJ (2006) Evolution of melanopsin
photoreceptors: Discovery and characterization of a new melanopsin gene in
non-mammalian vertebrates PLoS Biology 4(8):e254

Melyan Z&s_comma; Tarttelin EE&s_comma; Bellingham J&s_comma; Lucas RJ&s_comma; Hankins MW (2005). Addition
of human melanopsin renders mammalian cells photoresponsive. Nature

Lucas RJ&s_comma; Hattar S&s_comma; Takao M&s_comma; Berson DM&s_comma; Foster RG&s_comma; Yau K-W (2003) Diminished
pupillary light reflex at high irradiances in melanopsin-knockout mice.
Science 299:245-247.

東京大学大学院 理学系研究科 生物化学専攻 深田 吉孝
      医学系研究科 神経機能解明ユニット 河崎 洋志