***** seminarMLから情報転載 *****


東大医科研学友会セミナーをご案内いたします。
Wu先生は長く米国テキサス大学でご活躍の後、現在は台湾においてアメ
リカのNIHに相当する組織の長という要職をつとめておられま
す。現在も様々な研究を展開されておられますが今回は長年続けてこら
れたCOX-2についてお話頂きます。
みなさまのご来聴をお待ちしております。

開催日時: 平成19 年 10月10日(水)1
5:00~16:00

開催場所:  東京大学医科学研究所アムジェンホール大会議室
(地下鉄南北線白金台駅下車)

講師氏名:  Dr. Kenneth Kun-Yu Wu&s_comma; M.D.&s_comma; Ph.D.
Distinguished investigator and president
Acting director&s_comma;
National Health Research Institutes&s_comma; Zhu-nan&s_comma; Miaoli&s_comma; Taiwan

演  題: Cyclooxygenase-2 (COX-2) derived prostaglandins in
embryo and embryonic stem cell (ESC) development and survival

概  要: 

COX-2 occupies a pivotal position in synthesis of biologically active
prostaglandins. Overexpression of COX-2 has been causally linked to
inflammatory disorders&s_comma;
cancer&s_comma; atherosclerosis and neurodegenerative disorders. On the other
hand&s_comma; COX-2 derived PGS such as PGI2 protects cells from apoptosis.
Our recent work shows that PGI2 production by endothelial cells (EC)
via COX-2 protects ECs from apoptosis via PPARα-mediated
14-3-3ε upregulation. COX-2 derived PGI2 plays a crucial role
in murine embryo development in vitro. The action of PGI2 is also
mediated via PPARα as two-cell embryos derived from
PPARα knockout mice exhibit a retarded development into mature
blastocytes and has impaired implantation. PGI2-type membrane
receptor&s_comma; IP is less important. However&s_comma; two-cell embryos from IP-/-
mice develop in a slower rate than two-cell embryos from wild-type
mice. COX-2 plays a crucial role in protecting mouse ESC from
apoptosis. However&s_comma; mESCs do not have detectable PGI synthase and do
not produce PGI2. In contrast&s_comma; they express PGE synthases and produce
abundant PGE2. Our recent work suggests that COX-2 derived PGE2
protects ESC from apoptosis via EP2 receptor-mediated Akt activation.
Work is in progress to determine whether PGE2 and PGD2 are involved
in regulating ESC renewal&s_comma; proliferation and differentiation.

世話人:清木 元治、○渡辺 すみ子



seminarMLに関する情報は「バイオ関係者、皆のホームページ」特選MailingList_Forum欄でアクセスできる。