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9.13神経生化学セミナーのご案内/Neurochemistry Seminar Announcement

Title: Calcium Channels and Synaptic Plasticity
Lecturer: William A. Catterall&s_comma; PhD
Professor and Chairman&s_comma; Department of Pharmacology&s_comma; University of Washington at
Seattle

Time: September 13&s_comma; 2007 (Thu) 17:00~18:00
Place: Room 1304B (Seminar Room 7)&s_comma;13th floor&s_comma; New Medical Research Building
Host: Haruhiko Bito&s_comma; Department of Neurochemistry (hbito@m.u-tokyo.ac.jp)
Supported by Neuroscience Lecture Series&s_comma; Center for Integrated Brain Medical
Science&s_comma; a 21st Century COE Program from MEXT.

P/Q-type Ca current through Cav2.1 channels initiate synaptic transmission and
are regulated by calmodulin (CaM) at a site in the C-terminal containing an
IQ-like motif and a CaM binding domain (CBD). Brief&s_comma; local increases in Ca2+
support high affinity binding of the C-terminal lobe of CaM to the IQ-like
domain&s_comma; which causes facilitation. Sustained increases in Ca support binding of
the N-terminal lobe of CaM to the CBD&s_comma; which causes inactivation. The neuronal
calcium sensor protein CaBP1 binds to the Cav2.1 channel&s_comma; displaces CaM&s_comma; and
enhances inactivation&s_comma; whereas VILIP-2 slows Ca2+/CaM-dependent inactivation and
enhances facilitation. To examine the role of this regulation in synaptic
plasticity&s_comma; we expressed Cav2.1 channels in sympathetic neurons. Synaptic
transmission initiated by wild-type Cav2.1 channels showed facilitation&s_comma;
augmentation&s_comma; and depression&s_comma; but this short-term synaptic plasticity was lost
in mutant channels lacking the IQ-like domain and CBD. Evidently&s_comma; regulation of
Cav2.1 channels through interaction with calcium sensor proteins is responsible
for short-term synaptic plasticity at this model synapse.

Catterall先生は、電位依存性カルシウムチャンネルの構造活性相関ならびに生理的制御
機構について、これまで数多くの先駆的なお仕事をなされてきました。今般、日本神経科
学学会に際してご来日される折に、東大にてご講演いただく機会を得ましたので、どうか
奮ってご参加下さい。

--
尾藤晴彦
東京大学大学院医学系研究科
脳神経医学専攻 神経生化学分野
〒113-0033 東京都文京区本郷7-3-1
e-mail: hbito@m.u-tokyo.ac.jp
Tel: 03-5841-3559 Fax: 03-3814-8154




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