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神経生化学セミナーのご案内/Neurochemistry Seminar Announcement

Seminar 1: "Neuronal selection and competition in memory formation: The role of
CREB"

Lecturer: Sheena Josselyn&s_comma; Ph.D.
Affiliation: Canada Research Chair in Molecular and Cellular Cognition&s_comma; Program
in Integrative Biology&s_comma; The Hospital for Sick Children Research Institute&s_comma;
Toronto
and Assistant Professor of Physiology&s_comma; University of Toronto&s_comma; Toronto&s_comma; Canada

Time: Feb 28th 2007 (Wed) 11:30~12:15
Place: Room 1303 (Seminar Room 5)&s_comma; 13th floor&s_comma; New Medical Research Building

Competition between neurons is necessary for refining neural circuits during
development and may be important for selecting which neurons participate in a
given memory in the adult brain. To examine neuronal selection and competition
during memory formation&s_comma; we manipulated CREB function in subsets of neurons.
Here we show that changes in relative CREB function bias the probability that
individual lateral amygdala neurons are recruited into a fear memory trace. Our
results suggest a competitive model underlying memory formation in which
eligible neurons are selected to participate in a memory trace as a function of
their relative CREB activity during learning.

Seminar 2: "Preferential incorporation of adult-generated granule cells into
spatial memory networks in the dentate gyrus"
Lecturer: Paul Frankland&s_comma; Ph.D.
Affiliation: Canada Research Chair in Cognitive Neurobiology&s_comma; Program in
Neurosciences and Mental Health&s_comma; The Hospital for Sick Children Research
Institute&s_comma; Toronto
and Assistant Professor of Physiology&s_comma; University of Toronto&s_comma; Toronto&s_comma; Canada

Time: Feb 28th 2007 (Wed) 12:15~13:00
Place: Room 1303 (Seminar Room 5)&s_comma; 13th floor&s_comma; New Medical Research Building

Throughout adulthood new neurons are continuously added to the dentate gyrus&s_comma; a
hippocampal sub-region that plays a critical role in spatial learning. However&s_comma;
whether or not these adult-generated granule cells become functionally
integrated into memory networks is not known. Our studies have used
immunohistochemical approaches to visualize the recruitment of new neurons into
circuits supporting water maze memory in intact animals. We show that as new
granule cells mature they are increasingly likely to be incorporated into
circuits supporting spatial memory in mice. By the time they are 4 weeks or
older they are more likely than existing granule cells to be recruited into
circuits supporting spatial memory. This preferential recruitment supports the
idea that new neurons make a unique contribution to memory processing in the
dentate gyrus.

Host: Haruhiko Bito&s_comma; Department of Neurochemistry (tel: 03-5841-3560)
Supported by Neuroscience Lecture Series&s_comma; Center for Integrated Brain Medical
Science&s_comma; a 21st Century COE Program from MEXT.

--
尾藤晴彦
東京大学大学院医学系研究科
脳神経医学専攻 神経生化学分野



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