***** seminarMLから情報転載 *****


開催日時: 平成18年11月1日(水) 13:30~14:30

開催場所: 東大医科学研究所合同ラボ棟2階会議室


講 師: Christopher Kemp&s_comma; PhD

所 属: Full Member&s_comma; Division of Human Biology
       Fred Hutchinson Cancer Research Center

演  題: The genetics and biology of tumor suppression by p27/Kip1

概  要:The expression of the Cdk inhibitor p27 is reduced in many diverse
human cancer types. Importantly&s_comma; reduced expression or p27 in tumors
correlates with poor prognosis for cancer of the breast&s_comma; lung&s_comma; prostate&s_comma;
colon&s_comma; ovary and other tumor types. Our studies&s_comma; using mouse models&s_comma;
revealed that p27 was a haploinsufficient tumor suppressor in multiple
tissues including stomach&s_comma; small intestine&s_comma; colon&s_comma; lung&s_comma; skin&s_comma; and ovary. We
further showed that loss of p27 cooperates with multiple oncogene and tumor
suppressor gene pathways&s_comma; suggesting that p27 is almost universally involved
in cancer progression. Our current studies are focusing on the mechanisms of
tumor suppression by p27 and how p27 is misregulated during cancer

?Kemp&s_comma; C.J. “Multistep skin cancer in mice as a model to study the
evolvability of cancer cells.” Semin. Cancer Biol.&s_comma; 15:460-473&s_comma; 2005.
?Payne&s_comma; S.E. and Kemp&s_comma; C.J. “Tumor suppressor genetics.” Carcinogenesis
26:2031-2045&s_comma; 2005.
?Besson&s_comma; A.&s_comma; Gurian-West&s_comma; M.&s_comma; Chen&s_comma; X.&s_comma; Kelly-Spratt&s_comma; K.&s_comma; Kemp&s_comma; C.J.&s_comma;
Roberts&s_comma; J.M. “A pathway in quiescent cells that controls p27/Kip1
stability&s_comma; subcellular localization&s_comma; and tumor suppression.” Genes and
Devel.&s_comma; 20:47-64&s_comma; 2006.

世話人: ○渡辺 すみ子、古川 洋一

渡辺 すみ子、教授
東京都港区白金台 4-6-1
Phone 03-5449-5663/5664
FAX 03-5449-5474