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第2回国際生物分子と関連化合物シンポジウム
2nd International Symposium on Biomolecules and Related Compounds(2ndISB)

主管 2nd ISB組織委員会
日時 平成18年11月10日(金)~12日(日)
会場 京都薬科大学 愛学館(京都市山科区御陵中内町5)
共催 京都薬科大学21世紀COEプログラム「伝承からプロテオームまでの統合創薬の開拓」
京都薬科大学 創薬科学フロンティア研究センター
協賛 日本薬学会 日本化学会 日本農芸化学会 日本生化学会 有機合成化学協会 日本ペプチド学会 日本蛋白質科学会

参加登録
HP上の参加登録用紙に必要事項を記入し、ファックス又は郵送にてお申込ください。

参加登録費
学生5000円、大学・研究機関10000円、企業関係15000円(10月17日以降のお申込の場合は各5000円増し)

参加登録費には、バッグ、要旨集、飲み物、歓迎レセプション、ランチ、懇親会などが含まれます。

支払方法
クレジットカード(推奨)、または銀行振込。

申込方法、最新情報など詳しくはホームページ
http://www.kyoto-phu.ac.jp/2nd_isb/をご覧ください。

問合・申込先
〒607-8412 京都市山科区御陵四丁野町1
京都薬科大学創薬科学フロンティア研究センター
2ndISB組織委員長・木曽良明(担当・シンポジウム事務局)
TEL:075-595-4636
FAX:075-595-4787
E-mail:isb2@mb.kyoto-phu.ac.jp

SCIENTIFIC PROGRAM

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Friday November 10 2006
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1:40 - 1:50 PM Welcome & Introductory Remarks

1:50 - 3:35 PM
Invited Lectures
Chemical Protein Synthesis
Stephen Kent (University of Chicago U.S.A.)

The Ins and Outs of K+ Channels Revealed Through Synthesis
Franciz I. Valiyaveetil; Matthew Sekedat; Manuel Leonetti; Roderick Mackinnon and Tom W. Muir (The Rockefeller University U.S.A.)

Developing New Antivirals by Targeting Critical Viral/Human Protein Interactions
Ernesto Freire (Johns Hopkins University U.S.A.)

4:05 - 5:45 PM
Oral Presentations
Hydroxymethylcarbonyl Isostere-Based Inhibitors against HIV Protease and Malarial Plasmepsin
K. Hidaka; T. Kimura; N. Katsuki; K. F. McDaniel; T. Dekhtyar; L. Colletti; A. J. Ruben; E. Freire; J. C. Clemente; B. M. Dunn; R. McKenna; Y. Hayashi and Y. Kiso (Kyoto Pharmaceutical University Japan; Abbott Laboratories; Johns Hopkins University; University of Florida U.S.A.)

From Peptidic Substrate to Small Inhibitor Possessing Non-Natural Amino Acids: A Summary on HTLV-I Protease Inhibitor Optimization Studies
J-T. Nguyen; A. Itami; H. Maegawa; K. Nishiyama; T. Kimura and Y. Kiso (Kyoto Pharmaceutical University Japan)

Invited Lecture
Molecular Basis for Development of Alzheimer’s Disease
Katsuhiko Yanagisawa (National Center for Geriatrics and Gerontology Japan)

Oral Presentation
Development of Potent ß-Secretase (BACE1) Inhibitors Containing Phenylnorstatine
Z. Ziora; Y. Hamada; D. Shuto; P. Liu; N. Igawa; H. Ikari; J.-T. Nguyen; K. Hidaka; T. Kimura; Y. Hayashi; S. Ishiura; Y. Kiso (Kyoto Pharmaceutical University; University of Tokyo Japan)

Invited Lecture
The Discovery of Novel BACE Inhibitors
Joseph P. Vacca; Philippe G. Nantermet; Samuel L. Graham; Stacey R. Lindsley; Keith P. Moore; Hemaka A. Rajapakse; Mary Beth Young; Georgia B. McGaughey; Lawrence C. Kuo; Sanjeev K. Munshi; Dennis Colussi; Ming-Tain Lai and Beth L. Pietrak; Harold G. Selnick (Merck Research Laboratories U.S.A.)

6:00 - 6:40 PM POSTER SESSION I
6:40 PM - Opening Reception

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Saturday November 11 2006
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9:00 - 10:45 AM
Oral Presentations
Imitating protein ß-hairpins with more robust ß-peptide folds
Carsten Baldauf and María Teresa Pisabarro (Biotechnologiezentrum der TU Dresden Germany)

“Click Peptide” based on the “O-acyl isopeptide method”: a novel synthetic method of peptides and synthesis of Alzheimers amyloid ß peptide analogues
Youhei Sohma; Atsuhiko Taniguchi; Taku Yoshiya; Fukue Fukao; Setsuko Nakamura; Yousuke Chiyomori; Takuma Okada; Keisuke Ikeda; Tooru Kimura; Yoshio Hayashi; Shun Hirota; Katsumi Matsuzaki and Yoshiaki Kiso (Kyoto Pharmaceutical University; Kyoto University Japan)

Invited Lecture
Switch-Peptides as Folding Precursors: At the Crossroad of Concepts
M. Mutter; S. Dos Santos; A. Chandravarkar; B. Mandal R. Mimna; K. Murat; L. Saucède; M. Camus; J. Bérard; G. Tuchscherer (Ecole Polytechnique Fédérale de Lausanne Switzerland)

Oral Presentations
Conformational changes during apoplastocyanin folding observed by photocleavable modification and transient grating
S. Hirota; Y. Fujimoto; J. Choi; N. Baden; N. Katagiri; M. Akiyama; R. Hulsker; M. Ubbink; T. Okajima; T. Takabe; N. Funasaki; Y. Watanabe; M. Terazima (Kyoto Pharmaceutical University; Nagoya University; Kyoto University Japan; Leiden University The Netherlands; Osaka University; Meijo University Japan)

Toward Smarter Delivery of Paclitaxel: Application of O-N Intramolecular Acyl and Alkoxycarbonyl Migrations
M. Skwarczynski; M. Noguchi; Y. Sohma; S. Hirota; T. Kimura; Y. Hayashi; Y. Kiso (Kyoto Pharmaceutical University Japan)

Total Synthesis of (-)-Diospongins A and B
Sudhir Hande; Nobuyuki Kawai and Junichi Uenishi (Kyoto Pharmaceutical University Japan)

11:15 - 1:00 PM
Polar Interface in Liquid Phospholipid Bilayer Membrane: Heterogeneity Dynamics and Intermolecular Relations
Viktor V. Volkov; Riccardo Chelli; Yuji Takaoka; Roberto Righini (European Laboratory for Nonlinear Spectroscopy; Universita di Firenze; Consorzio Interuniversitario Nazionale per la Scienza e Tecnologia dei Materiali Italy; Taisho Pharmaceutical Co. Ltd. Japan)

Aeromonas hydrophila Targets Endothelin System in a Thermoregulated Manner
Said Kamal Abolghait; Yukihiro Akeda; Vlademir V. Cantarelli; Toshio Kodama; Tetsuya Iida and Takeshi Honda (Osaka University Japan; Weinmann Laboratorio Brazil)

Quantitative Evaluation of Each Catalytic Subsite of Cathepsin B for Inhibitory Activity Based on Inhibitory Activity-Binding Mode Relationship of Epoxysuccinyl Inhibitors by X-ray Structure Analyses of Complexes
Koji Tomoo; Daiya Watanabe; Atsushi Yamamoto; Keita Matsumot;o Mitsuo Murata; Kunihiro Kitamura and Toshimasa Ishida (Osaka University of Pharmaceutical Sciences; Taisho Pharmaceutical Co. Ltd. Japan)

Invited Lectures
Molecular Mechanisms of Phytochrome Signaling
Toshimasa Yamazaki; Toshitatsu Kobayashi; Masaki Mishima; Ryo Tabata; Rintaro Suzuki; Makoto Takano and Chojiro Kojima (National Institute of Agrobiological Sciences; Nara Institute of Science and Technology Japan)

Chemical Modification of Interleukin-8 for a Better Understanding of Function
Annette Beck-Sickinger (University of Leipzig Germany)

2:00 - 2:40 PM POSTER SESSION II

2:50 - 4:40 PM
Quaternary Protein Mimetics
James Tam (Nanyang Technological University Singapore; Scripps Research Institute U.S.A.)

Oral Presentations
Branched peptide magic bullets for tumor targeting
C. Falciani; A. Pini; M. Fabbrini; B. Lelli; S. Pileri; J. Brunetti; L. Lozzi; S. Scali; S. Bindi and L. Bracci (University of Siena Italy)

Microwave-Assisted Organic Synthesis for the Preparation of Biomolecules
G. Dibó; B. Bacsa; C.O. Kappe (Eötvös Loránd University Hungary; Karl-Franzens University Austria)

A simple solid phase synthesis of spiroimidazolidinone derivative libraries
Muriel Amblard; Lidia Feliu; David Font; Roger Soley; Julien Tailhades; Gilles Subra Jean Martinez (Laboratoire des Amino acides Peptides et Protéines -- UMR-CNRS France; Universitat de Girona Spain)

Field-flow fractionation (FFF) for analysis of natural or biomolecules
Seungho Lee (Hannam University Korea)

5:10 - 6:55 PM
Adenosine and Guanosine Analogs Inhibit B. anthracis Spore Germination and Prevent Macrophage Killing
Monique Akoachere; Tetyana O. Dodatko; Raynal Squires; Jürgen Brojatsch; Ernesto Abel-Santos (University of Nevada; Albert Einstein College of Medicine U.S.A.)

Invited Lecture
Synthesis and Biological Evaluation of Artificial Bent DNA
A. Matsuda; S. Murata; Y. Mizumura; S. Ichikawa (Hokkaido University Japan)

Oral Presentation
Medicinal Chemistry and Chemical Biology of A New Microtubule Targeting Agent
Yoshio Hayashi; Yuri Yamazaki; Yoshiaki Kiso; Kyoko Kohno; Kentaro Takayama; Takuya Fujita; Akira Yamamoto; Saskia Neuteboom; Ana M. Barral; Benjamin Nicholson; Barbara Potts; G. Kenneth Lloyd (Kyoto Pharmaceutical University Japan; Nereus Pharmaceuticals U.S.A.)

Invited Lecture
Breaching Biological Barriers: New in vivo Imaging Tools and Therapeutic Strategies Based on Novel Drug Delivery Systems
Paul A. Wender (Stanford University U.S.A.)

7:00 PM - Mixer

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Sunday November 12 2006
========================
9:00 - 10:55 AM
Oral Presentation
Cytokines production inhibitors from the leaves of Hydrangea macrophylla var. thunbergii
Hisashi Matsuda; Qilong Wang; Koudai Matsuhira; Seikou Nakamura; Dan Yuan; Masayuki Yoshikawa (Kyoto Pharmaceutical University Japan; Shenyang Pharmaceutical University China)

Invited Lectures
From Amino Acids to Peptide Isosteres: Implication to Genome-lead Drug Discovery
Nobutaka Fujii (Kyoto University Japan)

Synthesis and Biological Evaluations of Ghrelin Ligands - Example of an Orally Active Agonist
Jean Martinez (Universite Montpellier France)

Structural Development Studies of Nuclear Receptor Ligands
Yuichi Hashimoto (The University of Tokyo Japan)

11:25 - 1:00 PM
Design and Synthesis of Protein Phosphatase Inhibitors
Mikiko Sodeoka (RIKEN Japan)

Developing Renin Inhibitors as Antihypertensives
Juergen Maibaum (NOVARTIS Pharma AG Switzerland)

The Astellas Drug Discovery Paradigm: Diversity as a Strength
Mitsuaki Ohta (Astellas Pharma Japan)

1:00 PM - Closing Remarks

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POSTER PRESENTATIONS
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P-1 N-S Acyl Shift Reaction on Peptide Backbone and Its Application to Preparation of Peptide Thioesters
Kenichiroh Nakamura; Toru Kawakami; Hironobu Hojo; Yoshiaki Nakahara; Saburo Aimoto (Osaka University; Tokai University Japan)

P-2 “O-Acyl Isopeptide Method” for the Efficient Synthesis of Difficult Sequence -containing Peptides: Development of “O-Acyl Isodipeptide Unit”
S. Nakamura; T. Yoshiya; A. Taniguchi; Y. Sohma; F. Fukao; N. Abe; N. Ito; M. Skwarczynski; T. Kimura; Y. Hayashi; Y. Kiso (Kyoto Pharmaceutical University Japan)

P-3 “O-Acyl isopeptide Method”: Racemization-free Segment Condensation in Peptide Synthesis
T. Yoshiya; Y. Sohma; Y. Hamada; T. Kimura; Y. Hayashi; Y. Kiso (Kyoto Pharmaceutical University Japan)

P-4 “Click Peptide”: Chemical Biology-Oriented Synthesis of Alzheimer’s Disease-Related Aß Analogues
A. Taniguchi; Y. Sohma; M. Kimura; T. Yoshiya; T. Okada; K. Ikeda; Y. Hayashi; T. Kimura; S. Hirota; K. Matsuzaki; Y. Kiso (Kyoto Pharmaceutical University; Kyoto University Japan)

P-5 Design and Synthesis of ß-Secretase Inhibitors: Modification of the P4 Moiety for Improvement of Inhibitory Activity in Cultured Cells
Yoshio Hamada; Naoto Igawa; Hayato Ikari; Zyta Ziora; Jeffrey-Tri Nguyen; Abdellah Yamani; Koushi Hidaka; Tooru Kimura; Kazuki Saito; Yoshio Hayashi; Maiko Ebina; Shoichi Ishiura and Yoshiaki Kiso (Kyoto Pharmaceutical University; University of Tokyo Japan)

P-6 Structure-Activity Relationships of Tripeptide Mimetic against Malarial Plasmepsin
K. Hidaka; T. Kimura; M. Kamiya; Y. Tsuchiya; Y. Hayashi; A. J. Ruben; E. Freire and Y. Kiso (Kyoto Pharmaceutical University Japan; Johns Hopkins University USA)

P-7 Malignant Conformation of the 42-mer Amyloid ß-peptide folds
K. Irie; K. Murakami; Y. Masuda; H. Ohigashi; H. Hara; R. Ohashi; K. Takegoshi; M. Nagao; T. Shimizu and T. Shirasawa
(Kyoto University; Bruker Biospin K. K.; Tokyo Metropolitan Institute of Gerontology Japan)

P-8 Interactions between SLH modules and cell walls derived from Clostridium josui Clostridium stercorarium and Clostridium thermocellum
G. Zhao; M. Sakka; T. Kimura; K. Sakka (Phoenix Lives Institute Co. Ltd.; Mie University Japan)

P-9 ATP-dependent Interactions between Escherichia coli MinC/MinD Complex and Phospholipid Membrane
Takashi Okuno; Shun Hirota and Noriaki Funasaki (Kyoto Pharmaceutical University Japan)

P-10 Size Characterization of Polymeric Core/Shell DDS Nanoparticles using Flow Field-flow Fractionation (FlFFF) Dong Young Kang; Mi Jung Kim; Sung Kyun Hahn; Soon Hong Yuk; Seungho Lee (Hannam University Korea)

P-11 Purification and Analysis of a Biosurfactant Produced by Pseudomonas sp. G11 using Asymmetrical Flow Field-Flow Fractionation (AsFlFFF)
Sung Kwang Cho; So Hee Shim; Kyeong Ryang Park; Seong-Ho Choi; Seungho Lee (Hannam University Korea)

P-12 Retention and Zone Broadening of Proteins and Pullulans in Asymmetrical Flow Field-flow Fractionation (AsFlFFF)
Eunsun Ji; Chul Hun Eum; Jong Shin Yu; Kuk Ro Yoon; Seungho Lee (Hannam University; Korea Institute of Geoscience and Mineral Resources; Korea basic Science Institute Korea)

P-13 GET-Tagging/Digestion Approach for Highly Sensitive Phosphorylation-Site Localization of Phosphoproteome
Eun Sun Ji; Yeong Hee Ahn; Kun Cho; Hyun Ju Kang; Hoguen Kim; Seungho Lee and Jong Shin Yoo (Korea Basic Science Institute; Yonsei University; Hannam University Korea)

P-14 Immobilization of Horseradish Peroxidase (HRP) onto Polyaniline and poly(aniline-co-2-aminophenol) Electrode and Their Application for H2O2 Sensing
Kang-Deuk Seo; Seong-Dae Oh; Jeong-Seon Yu and Seong-Ho Choi (Hannam University South Korea)

P-15 Patterning of Biomolecules by using the Functionalized Polystyrene Nanoparticle for Biosensor
Min Seok Kim; Seok-Gn Ryu; Jeong Seon Yu; Kuk Ro Yoon and Seong-Ho Choi (Hannam University Republic of Korea)

P-16 Screening of Peptides Bound to Anthrax Protective Antigen by M13 Phage Display
Hyehyun Hwang; Kyoungmi Noh; Moon-Young Yoon (Hanyang University Korea)

P-17 Tautomerism and Structure of 4(3H)-Pyrimidinone Studied by IR Spectroscopy and Quantum Chemical Calculations
Adchara Padermshoke; Yukiteru Katsumoto; Misako Aida (Hiroshima University Japan)

P-18 Insilico Docking Studies of the Pheromone Binding Protein-Pheromone of the Peachtree Borer.
C. V. S. Siva Prasad; Sarvendra V Singh; Anamika Singh and N. Subbarao (Indian Institute of Information Technology; Jawaharlal Nehru University India)

P-19 Development of Phototaxel: First Photosensitive Prodrug of Paclitaxel
M. Skwarczynski; M. Noguchi; S. Hirota; Y. Sohma; T. Kimura; Y. Hayashi; Y. Kiso (Kyoto Pharmaceutical University Japan)

P-20 Oligoarginine Prodrugs Bearing Self-Cleavable Peptide Spacers for Effective Intestinal Absorption
Y. Hayashi; K. Takayama; Y. Suehisa; T. Fujita; S. Futaki; A. Yamamoto; Y. Kiso (Kyoto Pharmaceutical University; Kyoto University Japan)

P-21 Synthesis of poly(p-dioxanone) gafted poly(succinimide) Catalyzed by Candida antarctica Lipase B
Hee Jin Park; Kuk Ro Yoon (Hannam University Korea)

P-22 Enantioselective Hydrolysis of (RS)-Ketoprofen Ethyl Ester by Lipase-immobilized Biocatalyst
Jae-Chan Lee; Seong-Dae Oh; Seon-Mi Lee; Jeong-Ah Yoon and Seong-Ho Choi (Hannam University South Korea)

P-23 Chemo-enzymatic Synthesis of Polyoxin J
T. Nishiyama; T. Kajimoto; M. Node (Kyoto Pharmaceutical University Japan)

P-24 Development of a New Synthetic Route for Negamycin as a Potential Drug Lead against Duchenne Muscular Dystrophy
Yoshio Hayashi; Shigenobu Nishiguchi; Daisuke Hashimoto; Atsuko Ohta; Kei Asai; Jun-ya Hasegawa; Takahiro Kato; Tetsuya Kajimoto; Manabu Node; Yoshiaki Kiso (Kyoto Pharmaceutical University Japan)

P-25 Method for Coating Biodegradable on the m-Particle used by Surface-Initiated Polymerization (SIP)
Chang Sin Lee; Jong Jin Lee; Hee Jin Park; Kuk Ro Yoon; Bong Guen So; Jeong Seon Yu; Soo Min Lee (Hannam University Korea)

P-26 Synthesis and Characterization of Polylisyns Coworked Magnetic Nanoparticle by Sulfate in Sulfate Initiator Polymerization
Jong Jin Lee; Chang Sin Lee; Kuk Ro Yoon; Bong Guen So; Soo Min Lee (Hannam University Korea)

P-27 Microwave-Promoted Four-Component Synthesis of Morpholine Derivatives.
Thomas Regnier; Fabienne Beréé; Olivier Lavastre; Bertrand Carboni (University of Rennes 1 France)

P-28 Preparation of Hybrid Nanoparticle by Gamma-Irradiation and Their Antibacterial Efficiency for Vibrio parahaemolytics Vibrio cholerae and Vibrio vulnificus
Seong-Dae Oh; Seong-Ho Choi; Young-Hong Min and Byung-Eun Lee (Hannam University; Institute of Health and Environment South Korea)

P-29 Development of Odorless Hydrogen Sulfide Equivalent M. Matoba T. Kajimoto M. Node Kyoto Pharmaceutical University Japan

P-30 Preparation of ß-Substituted Allylsilanes and Their Electrophilic Reactions
Takuya Iwamoto; Masashi Ohmi; Nobuyuki Kawai and Junichi Uenishi (Kyoto Pharmaceutical University Japan)

P-31 Towards Asymmetric Synthesis of Axially Chiral Biaryls using Arenechromium Complexes and Gold(I) Catalyzed Cycloisomerization of Enynes
Christophe Michon; Junichi Uenishi and Motokazu Uemura (Kyoto Pharmaceutical University Japan)

P-32 Structure Stability and Biological Activity of Bioactive Peptides from Bovine a-Casein
Srinivas Sistla and V. Prakash (Central Food Technological Research Institute India)

P-33 Triterpene Saponins with Gastroprotective Anti-hyperlipidemic and Anti-allergic Effects from Tea Plant
M. Yoshikawa; Y. Kato; T. Morikawa; S. Nakamura; A. Nagatomo; H. Matsuda (Kyoto Pharmaceutical University; Kinki University Japan)

P-34 Search and Development for Antiallergic and Antiinflammatory Compounds from Thai Medicinal Plant Alpinia galanga
H. Matsuda; S. Nakamura; Q. Wang; M. Kubo; S. Ando; M. Yoshikawa; T. Morikawa; T. Yasuhaha; T. Morimoto; T. Manse; O. Muraoka (Kyoto Pharmaceutical University; Kinki University Japan)

P-35 Triterpene-saponins with Hepatoprotective Activities from the Flower-buds of Panax notoginseng and Panax ginseng
S. Nakamura; S. Sugimoto; H. Matsuda; T. Morikawa; K. Ninomiya; M. Yoshikawa (Kyoto Pharmaceutical University; Kinki University Japan)

P-36 Diterpene-alkaloids with Lipid Metabolism Promoting Activities from Egyptian herbal medicine Nigella sativa
F. Xu; T. Morikawa; H. Matsuda; K. Ninomiya; M. Yoshikawa (Kyoto Pharmaceutical University; Kinki University Japan)

P-37 Rotenoids and Flavonoids with Anti-invasion of HT1080 Anti-proliferation of U937 and Differentiation-inducing Activity in HL-60 from Erycibe expansa
H. Matsuda; K. Yoshida; F. Xu; Y. Asao; S. Takayama; S. Nakashima; K. Miyagaw;a M. Yoshikawa (Kyoto Pharmaceutical University Japan)

P-38 Serofendic Acid Protects against Degeneration of Nigral Dopaminergic Neurons in Hemiparkinsonian Rats
Y. Kitamura; M. Inden; K. Takata; T. Taniguchi; H. Sugimoto; A. Akaike (Kyoto Pharmaceutical University; Kyoto University Japan)

P-39 Changes in Distributions and Protein Levels of Actin Cytoskeleton-Regulatory Proteins during Postnatal Development in Rat Brain
K. Takata; Y. Kitamura; D. Tsuchiya; S. Shimohama; T. Taniguchi (Kyoto Pharmaceutical University; Kyoto University Japan)

P-40 Overexpression of Dominant-Negative Mutant Form of Presenilin 1 Causes an Impairment of Neurite Formation in Human Neuroblastoma SH-SY5Y Cells
D. Tsuchiya; Y. Kitamura; S. Shimohama; T. Taniguchi (Kyoto Pharmaceutical University; Kyoto University Japan)

P-41 Reconstruction of Tyrosine Hydroxylase-Positive Neurons and Locomotion in Planarian Regenerates
K. Nishimura; Y. Kitamura; T. Inoue; Y. Umesono; K. Yoshimoto; K. Agata and T. Taniguchi (Kyoto Pharmaceutical University; RIKEN Kobe; Kyoto University; Kyoto Prefectural University of Medicine Japan)

P-42 Proteasome Inhibitors Protect against Dopaminergic Neuronal Cell Death in Hemiparkinsonian Rats
D. Yanagisawa; Y. Kitamura; M. Inden; H. Sawada; S. Shimohama; T. Taniguchi (Kyoto Pharmaceutical University; Kyoto University Japan)

P-43 Distribution of DJ-1 and its Alteration in 6-hydroxydopamine-injected Rat Brain
T. Yanagida; M. Inden; K. Takata; Y. Kitamura; T. Taniguchi; T. Taira; H. Ariga (Kyoto Pharmaceutical University; Hokkaido University Japan)

P-44 Crystal structure of HIV protease complexed with KNI-272 at 1.1 Å resolution
M. Adachi; T. Tamada; K. Hidaka; Y. Hayashi; E. Freire; Y. Kiso; R. Kuroki (Japan Atomic Research Agency; Kyoto Pharmaceutical University Japan; Johns Hopkins University U.S.A.)