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7.7 神経生化学セミナーのご案内
(共催: 21世紀COE「脳神経医学の融合的研究拠点」 ニューロサイエンスレクチャーシリーズ)

演題: Finding the Synaptic Organizers

講師:梅森久視 博士 (Assistant Professor&s_comma; Molecular & Behavioral Neuroscience Institute/Department of Biological Chemistry/Neuroscience Program University of Michigan Medical School)

日時:  平成18年7月7日(金) 16:30~17:30
場所:  東大医学系研究科 教育研究棟 2階 N212号室 (第4セミナー室)
連絡先: 東大・院医・神経生化学  尾藤晴彦 (03-5841-3560)
共催:  21世紀COE「脳神経医学の融合的研究拠点」ニューロサイエンスレクチャーシリーズ

Neurons analyze and transmit information in our nervous system. Information is transferred from one neuron to another at functional contact sites called synapses. Precise assembly of synapses is critical for proper functioning of the nervous system. Synapses are formed by signaling between the presynaptic and postsynaptic cells. Postsynaptic cell-derived “presynaptic organizers” promote local differentiation of presynaptic axons into functional nerve terminals at sites of synaptic contact. We purified and identified such presynaptic organizers using clustering of synaptic vesicles in cultured neurons as an assay&s_comma; and examined their in vivo function using mouse mutants. We show that:
(1) In the cerebellum&s_comma; FGF22 is a critical presynaptic organizer (Umemori et al.&s_comma; Cell 118&s_comma; 257&s_comma; 2004).
(2) At the neuromuscular junction&s_comma; multiple muscle-derived cues act sequentially to organize presynaptic differentiation&s_comma; with FGF7/10/22&s_comma; laminin beta-2&s_comma; and collagen IV playing predominant roles in induction&s_comma; maturation&s_comma; and maintenance of functional motor nerve terminals&s_comma; respectively.
These results help explain how synapses are specifically organized in our nervous system.