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理研 BSI フォーラム・小胞体ストレスシグナルの生理と病理・浦野文彦博士( 5 月 23 日和光市[ 埼玉])


"ER stress signaling pathways in health and disease"

Fumihiko Urano&s_comma; MD&s_comma; PhD
Assistant Professor
University of Massachusetts Medical School

時間:14:00 - 15:00

Proteins are essential for the body to function properly. Proteins must fold into their proper three-dimensional structures to carry out their functions. Howe ver&s_comma; sometimes protein folding goes awry and malfolded proteins accumulate in cells. Numerous genetic and biochemical observations suggest that proteins that fail to fold properly are cytotoxic and impair cell function. This impairment is particularly important for the fate of non-renewable cells of long-lived organisms in which malfolded proteins can exert their deleterious effects over extended periods of time. The hypothesized contribution of malfolded proteins to progr essive cellular dysfunction fits the notion of chronic human diseases as a time-and use-dependent process. Examples of such diseases caused by the accumulation of malfolded proteins include Alzheimer’s disease and Parkinson’s disease. In this seminar&s_comma; I will summarize the function of stress signaling pathways elicited by the accumulation of malfolded protein in cells (ER stress

signaling pathways). Activation levels of these pathways define whether cells are in a healthy or disease state. It is therefore important to understand how to control the activation levels of ER stress signaling to cure protein malfoldin g diseases such as neurodegenerative diseases and diabetes.

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