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3.17 生物化学・神経生化学合同セミナーのご案内(共催: 21世紀COE「脳神経
医学の融合的研究拠点」 ニューロサイエンスレクチャーシリーズ)

演題: "Unraveling the Logic of Olfactory Circuit Assembly"

講師: Takaki Komiyama
Dept. of Biological Sciences (Liqun Luo laboratory)&s_comma; Neurosciences Program and Howard Hughes Medical Institute Stanford University

日時: 平成18年3月17日(金) 16:00~17:00
場所: 東大医学系研究科 本館小講堂 (1階)
連絡先: 理・生物化学 坂野仁 (sakano@mail.ecc.u-tokyo.ac.jp)
医・神経生化 尾藤晴彦 (hbito@m.u-tokyo.ac.jp)

共催: 21世紀COE「脳神経医学の融合的研究拠点」 ニューロサイエンスレクチャーシリーズ

Formation of precise neural circuits is essential for perception and behavior of organisms. As a model system to study mechanisms of neural circuit development&s_comma; we are using the olfactory system of Drosophila. The olfactory system demonstrates a dramatic example of precise neural circuits&s_comma; with single classes of olfactory receptor neuron axons and single classes of second order projection neuron dendrites forming one class to one class connections at the antennal lobe&s_comma; the first olfactory relay station in the brain. This organization is conserved from flies to mammals. We are studying cellular and molecular mechanisms of dendritic targeting of projection neurons&s_comma; as well as axon targeting of olfactory receptor neurons.

Komiyama T&s_comma; Luo L. (2006) Development of wiring specificity in the olfactory system. Curr Opin Neurobiol. 16: 67-73.
Komiyama et al. 2004 Olfactory receptor neuron axon targeting: intrinsic transcriptional control and hierarchical interactions. Nat Neurosci. 7 819-25
Komiyama et al. 2003 From lineage to wiring specificity. POU domain transcription factors control precise connections of Drosophila olfactory projection neurons. Cell. 112 157-167