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Seminar: NF-kappaB in the brain and lymphocytes

演題: Genetic approaches to unravel the role of NF-kappaB in regulating
brain functions and immunity

講演者: Dr. Sylvie Memet&s_comma; Unite de Mycologie Moleculaire&s_comma; Institut Pasteur
Paris&s_comma; France


場所:東京医科歯科大学 医歯学総合研究棟(1期棟)18階、保健衛生学講義室1 (わかりにくいようでしたら、学内で新棟の1期棟という建物をまずお尋ねください)

転写因子 NF-kappaBのリンパ球と脳における役割を、ノックアウトマウスのデータを中心に話していただく予定です。ご自由にご参加ください。

NF-kappaB is a crucial transcription factor mainly involved in immune and inflammatory responses&s_comma; cell growth and proliferation&s_comma; which is upregulated in a number of human cancers and diseases. To analyze basal and inducible NF-kappaB activity and understand the impact of its modulation on immune and brain functions in vivo&s_comma; several transgenic mouse models have been developed. These various models&s_comma; mice with a lacZ reporter gene under the control of kappaB sites&s_comma; knock-out mice for one or several IkappaBs&s_comma; or mice over-expressing in a conditional fashion a transdominant negative mutant of NF-kappaB (super-repressor) in neurons will be presented.


高次神経科学分野 田中光一 03-5803-5846
ウイルス制御学 山岡昇司 03-5803-5181