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Physiological and pathophysiological roles of lysophospholipid signaling

Date: July 27 (Wed) 18:00-19:00

Place: Microbiology Seminar Room (S311)&s_comma; 3rd fl. Faculty of Medicine&s_comma;
Building No.1&s_comma; The University of Tokyo
(東京大学医学部1号館3階 微生物学セミナー室 S311)

Speaker: Professor Jerold Chun&s_comma; Department of Molecular Biology&s_comma; Helen L. Dorris Child and Adolescent Neruopsychiatric Disorder Institute&s_comma; The Scripps Reserch Institute

Title: Physiological and pathophysiological roles of lysophospholipid signaling

Lysophospholipids have been shown in recent years to be signaling molecules that bring about diverse effects through cognate G-protein coupled receptors. There are now at least 9 receptors that mediate effects of LPA or S1P&s_comma; and a range of approaches has been directed at determining the physiological and pathophysiological roles of this lipid signaling system&s_comma; including pharmacological and genetic strategies. I will discuss examples of lysophospholipid signaling that have clear medical relevance&s_comma; from neural and non-neural models. Neural models include neuropathic pain&s_comma; multiple sclerosis and effects on neural stem/progenitor cells. Non-neural phenomena include a wide range of organ systems&s_comma; and a recent study demonstrating linkage between implantation and fertility via the third LPA receptor&s_comma; LPA3&s_comma;will be discussed.

Organized by Takao Shimizu
supported by 東京脂質談話会/第一製薬

KUNIEDA&s_comma; Kanako
Dept. of Biochemistry and Molecular Biology&s_comma;
Faculty of Medicine&s_comma; The University of Tokyo
7-3-1 Hongo&s_comma; Bunkyo&s_comma; Tokyo&s_comma; Japan&s_comma; 113-0033
Tel. 03-5802-2925 (ex. 23448)
Fax 03-3813-8732
URL http://biochem2.umin.jp/index.html