***** seminarMLから情報転載 *****


開催日時: 平成17年7月4日(月) 10:00~11:30

開催場所: 東京大学医科学研究所1号館2階会議室

講 師: Martin M. Matzuk&s_comma; MD&s_comma; PhD

所 属: Departments of Pathology&s_comma; Molecular and Cellular Biology&s_comma; and Molecular and Human Genetics&s_comma; and Developmental Biology Program&s_comma; Baylor College of Medicine&s_comma; Houston&s_comma; TX USA

演 題: TGF-beta Superfamily Signaling Pathways Throughout Development

概  要:It is now possible to modify the mouse genome to generate transgenic mice with precise genetic mutations&s_comma; and thousands of such models have now been created. For over a decade&s_comma; our laboratory has been using knockout and knockin transgenic mouse studies to define TGF-beta superfamily signaling pathways and function. In our efforts to understand reproduction in vivo&s_comma; we have produced transgenic knockout models for studying TGFb superfamily ligands (e.g.&s_comma; growth differentiation factor 9&s_comma; bone morphogenetic protein 15&s_comma; activins&s_comma; and inhibins)&s_comma; a ligand binding protein (e.g.&s_comma; follistatin)&s_comma; a receptor (e.g.&s_comma; ACVR2)&s_comma; a putative downstream receptor binding protein (e.g.&s_comma; FKBP12)&s_comma; downstream SMADs (e.g.&s_comma; SMAD5)&s_comma; and a downstream target (e.g.&s_comma; pentraxin 3). These investigations have revealed that TGF-beta superfamily ligands&s_comma; receptors&s_comma; SMADs&s_comma; and upstream and downstream regulators function in diverse developmental and physiological pathways. We are extending our studies by using new technology such as Cre-loxP strategies to address the in vivo roles of these and additional proteins in mammalian reproduction.

世話人  ○高次機能研究分野   中内 啓光

渡辺 すみ子
Phone 03-5449-5663/5664