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生物化学教室コロキウム

演者: Dr. Michael O. Hengartner
(Cold Spring Harbor Laboratory&s_comma; Cold Spring Harbor&s_comma; NY&s_comma; USA)

演題: Genetic control of programmed cell death in the nematode C. elegans

日時: 8月31日(月) 16:00 - 17:00
場所: 東京大学理学部3号館3階327号室
    (千代田線根津駅より徒歩5分、南北線東大前駅より徒歩8分)

----------------------------------------------- Michael Hengartner博士は線虫C. elegansのプログラム細胞死研究の第一人者です。

要旨:
Programmed cell death (apoptosis) is the process used by animals to get rid of superfluous or potentially dangerous cells. Over 15 genes have been iden tified that function in programmed cell death in the nematode Caenorhabditis elegans. These genes divide the process into four steps: Decision of individual cells whether to live or die&s_comma; execution of the death sentence&s_comma; recognition and engulfment of apoptotic cells by their neighbors&s_comma; and finally degradation of dead&s_comma; engulfed cells. Many of the cell death genes identified in C. elegans have functional homologues in mammals&s_comma; suggesting that nematodes and humans share a common&s_comma; conserved mechanism to kill cells.

In this talk&s_comma;I will summarize our current understanding of the molecular basis of cell death in C. elegans&s_comma; concentrating on 1) why some cells die while others survive; 2) how the death machinery functions to control the apoptotic cell fate;and 3) how apoptotic cells are recognized and engulfed.


世話人: 東大・理・生物化学・山本研 杉本 亜砂子
(03-3812-2111 内線4388、sugimoto@ims.u-tokyo.ac.jp)


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