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国立循環器病センター研究所COE国際シンポジウム

Sensing and Signaling in the Cardiovascular System

代表者:松尾壽之(国立循環器病センター研究所COE代
表者)

 国立循環器病センターは1993年に科学技術庁の中核的研究機関(COE)の指定を受け、循環器及びその疾患に関連する情報伝達について活発な研究活動を行う
と共に、数々の公開国際シンポジウムを開催し、国内外の著名な研究者を招いて関連分野研究者間の情報交換の場を提供してきました。

 この度そうした国際シンポジウムの一環として、このシンポジウムを計画しました。奮ってご参加いただきたく、ご案内いたします。


日時:1998年3月16(月) ー 17(火)日

場所:千里ライフサイエンスセンター(豊中市新千里東町1-4-2)
   地下鉄御堂筋線千里中央駅下車、徒歩1分

参加費:無料。来聴歓迎!



プログラム

Opening Remarks:

Hisayuki Matsuo (NCVC) (Mon. 9:00-9:10)



Session I. Biosynthesis and Cell Physiology of Prostaglandins (Mon. 9:10-12:30)

Chairpersons: S. Yamamoto (Tokushima Univ.)&s_comma; T. Tanabe (NCVC)

Speakers:

William L. Smith (Michigan State University)

Substrate Binding to Cyclooxygenases-1 and -2.

H. Inoue (NCVC)

Regulation of Prostacyclin and Thromboxane Synthesis.

Andrew J. Dannenberg (Cornell Medical Center)

Novel Approaches to Suppressing Prostaglandin Synthesis.

Jean Sirois (University of Montreal)

Hormonal Control of Prostaglandin G/H Synthase-2 Expression.

I. Morita (Tokyo Med. Dent. Univ.)

Effect of NO on Cyclooxygenase Activity.

M. Tsujii (Osaka Univ.)

Role of Prostaglandins in Apoptosis. (tentative)



II. Signaling by Cell Adhesion Molecules (Mon. 14:00-18:00)

Chairpersons: Y. Yoshida (Yamanashi Med. Univ.)&s_comma; K. Fujiwara (NCVC)

Speakers:

K. Kaibuchi (Nara Inst. Sci. Tec.)

Regulation of Cytoskeleton and Cell Adhesion by the Rho fami
ly small GTPases.

Susan Craig (Johns Hopkins Univ.)

Conformational Regulation of Vinculin&s_quote;s Ligand Binding Sites
: A Potential target of Signal Transduction Pathways for Cell
Motility and Cell Adhesion.

S. Tsukita (Kyoto Univ.)

Molecular Dissection of Tight Junctions.

Martin Schwartz (Scripps Inst.)

MAP Kinases and Rho Family GTPases in Integrin Signaling.

Marshall Corson (Univ. of Washington)

Endothelial Mechanotransduction: The Role of Protein Kinases.

.. M. Masuda (NCVC)

PECAM-1 as a Mechanotransduction Molecule.



III. Membrane Control of Contractility (Tue. 9:00-12:30)

Chairpersons: M. Iino (Tokyo Univ.)&s_comma; M. Shigekawa (NCVC)

Speakers:

Donald M. Bers (Department of Physiology&s_comma; Loyola Univeristy)

Cardiac Ca2+ Transport during EC Coupling and Relaxation.

J. Nakai (Natl. Inst. Physiol. Sci.)

Molecular Biology of Ca2+ Channels in Cardiac Excitation-con
traction

Coupling. (tentative)

M. Shigekawa (NCVC)

Molecular Physiology of Cardiac Na+/Ca2+ Exchanger.

Vivek J. Kadambi (Univ. of Cincinnati)

Transgenic Approaches to Elucidate the Role of Sarcoplasmic

Reticulum in Cardiac Contractility.

Y. Kimura (Yamaguchi Univ.)

Regulatory Mechanism of Calcium ATPase by Phospholamban.

Y. Imaizumi (Nagoya City Univ.)

Ca2+ Images and K+ Current Activation during Excitation-cont
raction Coupling

in Smooth Muscle Cells.



IV. Neural Regulation of the Heart (Tue. 14:00-18:00)

Chairpersons: M. Hori (Osaka Univ.)&s_comma; K. Sunagawa (NCVC)

Speakers:

Graeme Eisenhofer (NIH)

Clinical Assessment of Cardiac Sympathetic Nerve Function in
Human Health

and Disese.

T. Noshiro (Tohoku Univ.)

Regional Norepinephrine Spillover in Heart Failure.

Markus Haass (Univ. of Heidelberg)

Nicotine and Sympathetic Neurotransmission.

T. Akiyama (NCVC)

In Vivo Cardiac Microdialysis and Myocardial Ischemia

E. Hatta (Hokkaido Univ.)

Activation of Histamine H3 Receptors Inhibits Carrier-mediat
ed Norepinephrine Release in a Human Model
of Protracted Myocardial Ischemia.

K. Sunagawa (NCVC)

Neural Control of Heart Rate and Contractility.





組織委員:松尾壽之(委員長)、重川宗一、砂川賢二、田邉忠、藤原敬己

連絡先:565 大阪府吹田市藤白台 国立循環器病センター研究所

    循環器形態部 藤原敬己(Tel. 06-833-5012&s_comma; 内線2508;Fax. 06-872-8092)

URL:http//www.ncvc.go.jp/