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Sensing and Signaling in the Cardiovascular System




日時:1998年3月16(月) ー 17(火)日




Opening Remarks:

Hisayuki Matsuo (NCVC) (Mon. 9:00-9:10)

Session I. Biosynthesis and Cell Physiology of Prostaglandins (Mon. 9:10-12:30)

Chairpersons: S. Yamamoto (Tokushima Univ.)&s_comma; T. Tanabe (NCVC)


William L. Smith (Michigan State University)

Substrate Binding to Cyclooxygenases-1 and -2.

H. Inoue (NCVC)

Regulation of Prostacyclin and Thromboxane Synthesis.

Andrew J. Dannenberg (Cornell Medical Center)

Novel Approaches to Suppressing Prostaglandin Synthesis.

Jean Sirois (University of Montreal)

Hormonal Control of Prostaglandin G/H Synthase-2 Expression.

I. Morita (Tokyo Med. Dent. Univ.)

Effect of NO on Cyclooxygenase Activity.

M. Tsujii (Osaka Univ.)

Role of Prostaglandins in Apoptosis. (tentative)

II. Signaling by Cell Adhesion Molecules (Mon. 14:00-18:00)

Chairpersons: Y. Yoshida (Yamanashi Med. Univ.)&s_comma; K. Fujiwara (NCVC)


K. Kaibuchi (Nara Inst. Sci. Tec.)

Regulation of Cytoskeleton and Cell Adhesion by the Rho fami
ly small GTPases.

Susan Craig (Johns Hopkins Univ.)

Conformational Regulation of Vinculin&s_quote;s Ligand Binding Sites
: A Potential target of Signal Transduction Pathways for Cell
Motility and Cell Adhesion.

S. Tsukita (Kyoto Univ.)

Molecular Dissection of Tight Junctions.

Martin Schwartz (Scripps Inst.)

MAP Kinases and Rho Family GTPases in Integrin Signaling.

Marshall Corson (Univ. of Washington)

Endothelial Mechanotransduction: The Role of Protein Kinases.

.. M. Masuda (NCVC)

PECAM-1 as a Mechanotransduction Molecule.

III. Membrane Control of Contractility (Tue. 9:00-12:30)

Chairpersons: M. Iino (Tokyo Univ.)&s_comma; M. Shigekawa (NCVC)


Donald M. Bers (Department of Physiology&s_comma; Loyola Univeristy)

Cardiac Ca2+ Transport during EC Coupling and Relaxation.

J. Nakai (Natl. Inst. Physiol. Sci.)

Molecular Biology of Ca2+ Channels in Cardiac Excitation-con

Coupling. (tentative)

M. Shigekawa (NCVC)

Molecular Physiology of Cardiac Na+/Ca2+ Exchanger.

Vivek J. Kadambi (Univ. of Cincinnati)

Transgenic Approaches to Elucidate the Role of Sarcoplasmic

Reticulum in Cardiac Contractility.

Y. Kimura (Yamaguchi Univ.)

Regulatory Mechanism of Calcium ATPase by Phospholamban.

Y. Imaizumi (Nagoya City Univ.)

Ca2+ Images and K+ Current Activation during Excitation-cont
raction Coupling

in Smooth Muscle Cells.

IV. Neural Regulation of the Heart (Tue. 14:00-18:00)

Chairpersons: M. Hori (Osaka Univ.)&s_comma; K. Sunagawa (NCVC)


Graeme Eisenhofer (NIH)

Clinical Assessment of Cardiac Sympathetic Nerve Function in
Human Health

and Disese.

T. Noshiro (Tohoku Univ.)

Regional Norepinephrine Spillover in Heart Failure.

Markus Haass (Univ. of Heidelberg)

Nicotine and Sympathetic Neurotransmission.

T. Akiyama (NCVC)

In Vivo Cardiac Microdialysis and Myocardial Ischemia

E. Hatta (Hokkaido Univ.)

Activation of Histamine H3 Receptors Inhibits Carrier-mediat
ed Norepinephrine Release in a Human Model
of Protracted Myocardial Ischemia.

K. Sunagawa (NCVC)

Neural Control of Heart Rate and Contractility.


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